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dc.contributor.authorCarmona-Antonanzas, Gretaen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorTaggart, Johnen_UK
dc.contributor.authorLeaver, Michaelen_UK
dc.description.abstractBACKGROUND The ability to produce physiologically critical LC-PUFA from dietary fatty acids differs greatly among teleost species, and is dependent on the possession and expression of fatty acyl desaturase and elongase genes. Atlantic salmon, as a result of a recently duplicated genome, have more of these enzymes than other fish. Recent phylogenetic studies show that Northern pike represents the closest extant relative of the preduplicated ancestral salmonid. Here we characterise a pike fatty acyl elongase, elovl5, and compare it to Atlantic salmon elovl5a and elovl5b duplicates. RESULTS Phylogenetic analyses show that Atlantic salmon paralogs are evolving symmetrically, and they have been retained in the genome by purifying selection. Heterologous expression in yeast showed that Northern pike Elovl5 activity is indistinguishable from that of the salmon paralogs, efficiently elongating C18 and C20 substrates. However, in contrast to salmon, pike elovl5 was predominantly expressed in brain with negligible expression in liver and intestine. CONCLUSIONS We suggest that the predominant expression of Elovl5b in salmon liver and Elovl5a in salmon intestine is an adaptation, enabled by genome duplication, to a diet rich in terrestrial invertebrates which are relatively poor in LC-PUFA. Pike have retained an ancestral expression profile which supports the maintenance of PUFA in the brain but, due to a highly piscivorous LC-PUFA-rich diet, is not required in liver and intestine. Thus, the characterisation of elovl5 in Northern pike provides insights into the evolutionary divergence of duplicated genes, and the ecological adaptations of salmonids which have enabled colonisation of nutrient poor freshwaters.en_UK
dc.publisherBioMed Central Ltden_UK
dc.relationCarmona-Antonanzas G, Tocher DR, Taggart J & Leaver M (2013) An evolutionary perspective on Elovl5 fatty acid elongase: comparison of Northern pike and duplicated paralogs from Atlantic salmon. BMC Evolutionary Biology, 13, Art. No.: 85.
dc.rights© 2013 Carmona-Antoñanzas et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_UK
dc.subjectAtlantic salmonen_UK
dc.subjectElongase of very long-chain fatty acidsen_UK
dc.subjectNorthern pikeen_UK
dc.subjectParalogous genesen_UK
dc.subjectWhole-genome duplicationen_UK
dc.titleAn evolutionary perspective on Elovl5 fatty acid elongase: comparison of Northern pike and duplicated paralogs from Atlantic salmonen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleBMC Evolutionary Biologyen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorCarmona-Antonanzas, Greta|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorTaggart, John|0000-0002-3843-9663en_UK
local.rioxx.authorLeaver, Michael|0000-0002-3155-0844en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameAn evolutionary perspective on Elovl5 fatty acid elongase.pdfen_UK
Appears in Collections:Aquaculture Journal Articles

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