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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: N400 amplitude reduction correlates with an increase in pupil size
Author(s): Kuipers, Jan Rouke
Thierry, Guillaume
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Keywords: event-related potentials
pupil dilation
semantic processing
locus coeruleus
cognitive efficiency
LC–NE system
Issue Date: Jun-2011
Date Deposited: 29-Aug-2013
Citation: Kuipers JR & Thierry G (2011) N400 amplitude reduction correlates with an increase in pupil size. Frontiers in Human Neuroscience, 5, Art. No.: 61.
Abstract: Pupil dilation is classically associated with increase in cognitive load in humans. Here, we studied the potential link between human pupil dilation and meaning integration effort as indexed by event-related brain potentials (ERPs). We recorded pupil size variation and ERPs simultaneously while participants were presented with matching or unrelated picture-word pairs. Whilst relatedness in meaning between spoken words and pictures typically modulated ERPs, pupil size was also affected quickly after picture onset. Moreover, during the time-window associated with meaning integration, greater pupil dilation correlated with less negative N400 amplitudes elicited by unrelated pictures. Since pupil dilation has been linked to activity of the locus coeruleus-norepinephrine (LC-NE) system, these findings may provide new insights into the suggested link between human high-level cognitive function and activity of the LC-NE system.
DOI Link: 10.3389/fnhum.2011.00061
Rights: © 2011 Kuipers and Thierry. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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