Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorShires, Kate Len_UK
dc.contributor.authorHawthorne, James Pen_UK
dc.contributor.authorHope, Alexander M Jen_UK
dc.contributor.authorDudchenko, Paulen_UK
dc.contributor.authorWood, Emma Ren_UK
dc.contributor.authorMartin, Steven Jen_UK
dc.description.abstractThe laterodorsal nucleus (LDN) of the thalamus provides a prominent afferent projection to the postsubiculum (dorsal presubiculum). To characterize synaptic transmission in this pathway, we placed stimulating electrodes in the LDN and recorded fEPSPs elicited in the postsubiculum of urethane-anesthetized rats. LDN stimulation elicited a source-sink dipole between the deep and superficial layers of the postsubiculum, respectively, consistent with anatomical evidence for the termination of thalamic afferents in the superficial layers of the structure, and the existence of deep layer neurons with apical dendrites extending into these layers. Postsubicular fEPSPs were typically 0.5-1.0 mV in amplitude, with a peak latency of approximately 6 ms. Consistent with anatomical observations, the short onset latency of fEPSPs elicited by LDN stimulation, and their ability to follow a 60-Hz train of stimulation, indicate that the projection is monosynaptic. Paired-pulse stimulation revealed pronounced paired-pulse depression that was maximal at 100 ms, suggesting that initial release probabilities are high at LDN-postsubiculum synapses, in common with many neocortical pathways. A conventional tetanus protocol that yields LTP in hippocampal pathways had no effect on postsubicular fEPSPs, but long-term depression could be induced by 60-Hz stimulation. Drug infusion studies revealed that synaptic transmission in the LDN-postsubiculum projection is predominantly AMPA-receptor mediated. Rats were implanted with indwelling infusion cannulae targeting the postsubiculum, and, after a recovery period, were anaesthetized withurethane, and implanted with stimulating and recording electrodes. Infusion of CNQX almost completely abolished postsubicular fEPSPs, whereas D-AP5 had little effect. However, 60-Hz LTD was blocked by D-AP5 infusion, revealing that this form of synaptic plasticity is NMDA-receptor dependent.en_UK
dc.relationShires KL, Hawthorne JP, Hope AMJ, Dudchenko P, Wood ER & Martin SJ (2013) Functional connectivity between the thalamus and postsubiculum: Analysis of evoked responses elicited by stimulation of the laterodorsal thalamic nucleus in anesthetized rats. Hippocampus, 23 (7), pp. 559-569.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectdorsal presubiculumen_UK
dc.subjectsynaptic transmissionen_UK
dc.subjectsynaptic plasticityen_UK
dc.subjectlong-term depressionen_UK
dc.titleFunctional connectivity between the thalamus and postsubiculum: Analysis of evoked responses elicited by stimulation of the laterodorsal thalamic nucleus in anesthetized ratsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[hipo22114.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.relation.funderprojectLandmark processing in the mammalian brain: do head direction cells drive grid cells and spatial behaviour?en_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorShires, Kate L|en_UK
local.rioxx.authorHawthorne, James P|en_UK
local.rioxx.authorHope, Alexander M J|en_UK
local.rioxx.authorDudchenko, Paul|0000-0002-1531-5713en_UK
local.rioxx.authorWood, Emma R|en_UK
local.rioxx.authorMartin, Steven J|en_UK
local.rioxx.projectBB/L000040/1|Biotechnology and Biological Sciences Research Council|
Appears in Collections:Psychology Journal Articles

Files in This Item:
File Description SizeFormat 
hipo22114.pdfFulltext - Published Version7.5 MBAdobe PDFUnder Embargo until 3000-01-01    Request a copy

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.