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dc.contributor.authorLopez Jimena, Benjaminen_UK
dc.contributor.authorGarcia-Rosado, Estheren_UK
dc.contributor.authorThompson, Kimberlyen_UK
dc.contributor.authorAdams, Alexandraen_UK
dc.contributor.authorInfante, Carlosen_UK
dc.contributor.authorBorrego, Juan Jen_UK
dc.contributor.authorAlonso, Maria del Carmenen_UK
dc.description.abstractThe distribution of red-spotted grouper nervous necrosis virus (RGNNV) antigens was examined by immunohistochemistry in the nervous and non-nervous organs of juvenile European seabass (Dicentrarchus labrax) during the course of an intramuscular infection. Histological changes resulting from the infection were evaluated from 3 days to 2 months post-infection. The specific antibody response was also studied 2 months post-challenge. Viral proteins were present throughout the experimental period in the retina (inner nuclear layer, ganglion layer, outer limiting membrane, and outer plexiform layer), brain (cerebellum and tectum opticum), and liver (hepatocytes and endothelial cells). These proteins were also observed in the renal tubular cells, white pulp of spleen, and in fibroblasts and cartilage of caudal fin. This is the first report of RGNNV proteins appearing in these organs, where the immunostaining was only detected at certain sampling times after the onset of mortality. Brain and retina of virus-exposed fish showed high levels of vacuolation, while accumulation of fat vacuoles was observed in the liver. RGNNV infection also induced a specific antibody response as measured by an ELISA. In summary, this is the first study demonstrating the presence of viral proteins in cells of caudal fin, kidney and spleen of European seabass.en_UK
dc.publisherThe Korean Society of Veterinary Scienceen_UK
dc.relationLopez Jimena B, Garcia-Rosado E, Thompson K, Adams A, Infante C, Borrego JJ & Alonso MdC (2012) Distribution of red-spotted grouper nervous necrosis virus (RGNNV) antigens in nervous and non-nervous organs of European seabass (Dicentrarchus labrax) during the course of an experimental challenge. Journal of Veterinary Science, 13 (4), pp. 355-362.
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en_UK
dc.subjectEuropean seabassen_UK
dc.subjectFishes Diseasesen_UK
dc.subjectEuropean seabass fisheriesen_UK
dc.titleDistribution of red-spotted grouper nervous necrosis virus (RGNNV) antigens in nervous and non-nervous organs of European seabass (Dicentrarchus labrax) during the course of an experimental challengeen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleJournal of Veterinary Scienceen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Malagaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationCentro IFAPA, Spainen_UK
dc.contributor.affiliationUniversity of Malagaen_UK
dc.contributor.affiliationUniversity of Malagaen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorLopez Jimena, Benjamin|0000-0002-0141-8113en_UK
local.rioxx.authorGarcia-Rosado, Esther|en_UK
local.rioxx.authorThompson, Kimberly|en_UK
local.rioxx.authorAdams, Alexandra|en_UK
local.rioxx.authorInfante, Carlos|en_UK
local.rioxx.authorBorrego, Juan J|en_UK
local.rioxx.authorAlonso, Maria del Carmen|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameJournal of Veterinary Science 2012.pdfen_UK
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