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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Concurrent injection of a rhabdovirus-specific DNA vaccine with a polyvalent, oil-adjuvanted vaccine delays the specific anti-viral immune response in Atlantic salmon, Salmo salar L.
Author(s): Skinner, Lisa A
LaPatra, Scott E
Adams, Alexandra
Thompson, Kimberly
Balfry, Shannon K
McKinley, R Scott
Schulte, Patricia M
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Keywords: DNA vaccine
Adjuvant vaccine
Innate immune response
Lysozyme activity
Adaptive immune response
Neutralizing antibody
Antibody titre
Aeromonas salmonicida
Listonella anguillarum
Freshwater & Marine Ecology
Fish & Wildlife Biology & Management
Community & Population Ecology
Issue Date: Apr-2010
Date Deposited: 12-Jun-2013
Citation: Skinner LA, LaPatra SE, Adams A, Thompson K, Balfry SK, McKinley RS & Schulte PM (2010) Concurrent injection of a rhabdovirus-specific DNA vaccine with a polyvalent, oil-adjuvanted vaccine delays the specific anti-viral immune response in Atlantic salmon, Salmo salar L.. Fish and Shellfish Immunology, 28 (4), pp. 579-586.
Abstract: Vaccines are commonly used in salmonid aquaculture as a method of disease prevention. Although there is a substantial amount of published research regarding the immunological and physiological effects following the injection of different polyvalent vaccines and DNA vaccines, there are no published reports examining the physiological and immunological effects of concurrent vaccine injection, which is the situation encountered in aquaculture. Using key immunological parameters such as lysozyme activity and specific antibody titres we examined the short-term activation of the immune response of cultured Atlantic salmon (Salmo salar L.) following concurrent injection with a traditional, polyvalent, oil-adjuvanted vaccine (AV) and an IHNV-specific DNA vaccine (DV). Our results indicate that different aspects of the innate and adaptive immune responses are influenced in either a positive or negative manner. While concurrent vaccine injection elicited an increase in lysozyme activity, changes in antibody titre (Ab) were antigen specific. The production of anti-Aeromonas salmonicida Abs was significantly greater in the combined vaccine group at 296 degree days post-vaccine injection (dd pvi), while the production of anti-Listonella anguillarum Abs was significantly greater at 106 dd pvi in the combined vaccine group. Of even greater interest was the apparent delay in production of IHNV-specific neutralizing antibodies (NAb) when the DV was injected concurrently with the polyvalent AV. The results indicated that concurrent injection of a polyvalent oil-AV and a DV can be beneficial to the production of antibodies; however, the specific anti-viral response may be delayed.
DOI Link: 10.1016/j.fsi.2009.12.017
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