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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Demographic risk factors for classical and atypical scrapie in Great Britain
Author(s): Green, Darren
del Rio Vilas, Victor J
Birch, Colin P D
Johnson, Jethro
Kiss, Istvan Z
McCarthy, Noel D
Kao, Rowland R
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Keywords: Scrapie Etiology
Issue Date: Dec-2007
Date Deposited: 29-Jul-2009
Citation: Green D, del Rio Vilas VJ, Birch CPD, Johnson J, Kiss IZ, McCarthy ND & Kao RR (2007) Demographic risk factors for classical and atypical scrapie in Great Britain. Journal of General Virology, 88 (12), pp. 3486-3492.
Abstract: Following the bovine spongiform encephalopathy (BSE) crisis, the European Union has introduced policies for eradicating transmissible spongiform encephalopathies (TSEs), including scrapie, from large ruminants. However, recent European Union surveillance has identified a novel prion disease, ‘atypical’ scrapie, substantially different from classical scrapie. It is unknown whether atypical scrapie is naturally transmissible or zoonotic, like BSE. Furthermore, cases have occurred in scrapie-resistant genotypes that are targets for selection in legislated selective breeding programmes. Here, the first epidemiological study of British cases of atypical scrapie is described, focusing on the demographics and trading patterns of farms and using databases of recorded livestock movements. Triplet comparisons found that farms with atypical scrapie stock more sheep than those of the general, non-affected population. They also move larger numbers of animals than control farms, but similar numbers to farms reporting classical scrapie. Whilst there is weak evidence of association through sheep trading of farms reporting classical scrapie, atypical scrapie shows no such evidence, being well-distributed across regions of Great Britain and through the sheep-trading network. Thus, although cases are few in number so far, our study suggests that, should natural transmission of atypical scrapie be occurring at all, it is doing so slowly.
DOI Link: 10.1099/vir.0.83225-0
Rights: Published in the Journal of General Virology by the Society for General Microbiology (SGM).; IMMEDIATE OPEN ACCESS ARTICLE. Publisher statement: "SGM will arrange for the published article to be deposited in PubMed Central, with this version of the paper being freely accessible on publication of the definitive version in the online journal, to comply with the requirements of the Wellcome Trust and other funding bodies. Authors may also deposit the PDF version of the published paper in an institutional repository at this point".; Copyright © 2007 by the Society for General Microbiology.

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