|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Testosterone injection stimulates net protein synthesis but not tissue amino acid transport|
|Author(s):||Ferrando, Arny A|
Doyle, David J
Phillips, Stuart M
Wolfe, Robert R
|Keywords:||Amino nitrogen uptake|
Fractional breakdown rate
|Citation:||Ferrando AA, Tipton K, Doyle DJ, Phillips SM, Cortiella J & Wolfe RR (1998) Testosterone injection stimulates net protein synthesis but not tissue amino acid transport. American Journal of Physiology - Endocrinology and Metabolism, 275 (5), pp. E864-E871. http://ajpendo.physiology.org/content/275/5/E864.abstract|
|Abstract:||Testosterone administration (T) increases lean body mass and muscle protein synthesis. We investigated the effects of short-term T on leg muscle protein kinetics and transport of selected amino acids by use of a model based on arteriovenous sampling and muscle biopsy. Fractional synthesis (FSR) and breakdown (FBR) rates of skeletal muscle protein were also directly calculated. Seven healthy men were studied before and 5 days after intramuscular injection of 200 mg of testosterone enanthate. Protein synthesis increased twofold after injection (P less than 0.05), whereas protein breakdown was unchanged. FSR and FBR calculations were in accordance, because FSR increased twofold (P less than 0.05) without a concomitant change in FBR. Net balance between synthesis and breakdown became more positive with both methodologies (P less than 0.05) and was not different from zero. T injection increased arteriovenous essential and nonessential nitrogen balance across the leg (P less than 0.05) in the fasted state, without increasing amino acid transport. Thus T administration leads to an increased net protein synthesis and reutilization of intracellular amino acids in skeletal muscle.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Tipton_2002_Testosterone_injection_stimulates_net_protein_synthesis.pdf||Fulltext - Published Version||162.76 kB||Adobe PDF||Under Permanent Embargo Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved https://creativecommons.org/publicdomain/zero/1.0/
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.