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dc.contributor.authorFerrando, Arny Aen_UK
dc.contributor.authorTipton, Kevinen_UK
dc.contributor.authorDoyle, David Jen_UK
dc.contributor.authorPhillips, Stuart Men_UK
dc.contributor.authorCortiella, Joaquinen_UK
dc.contributor.authorWolfe, Robert Ren_UK
dc.description.abstractTestosterone administration (T) increases lean body mass and muscle protein synthesis. We investigated the effects of short-term T on leg muscle protein kinetics and transport of selected amino acids by use of a model based on arteriovenous sampling and muscle biopsy. Fractional synthesis (FSR) and breakdown (FBR) rates of skeletal muscle protein were also directly calculated. Seven healthy men were studied before and 5 days after intramuscular injection of 200 mg of testosterone enanthate. Protein synthesis increased twofold after injection (P less than 0.05), whereas protein breakdown was unchanged. FSR and FBR calculations were in accordance, because FSR increased twofold (P less than 0.05) without a concomitant change in FBR. Net balance between synthesis and breakdown became more positive with both methodologies (P less than 0.05) and was not different from zero. T injection increased arteriovenous essential and nonessential nitrogen balance across the leg (P less than 0.05) in the fasted state, without increasing amino acid transport. Thus T administration leads to an increased net protein synthesis and reutilization of intracellular amino acids in skeletal muscle.en_UK
dc.publisherAmerican Physiological Societyen_UK
dc.relationFerrando AA, Tipton K, Doyle DJ, Phillips SM, Cortiella J & Wolfe RR (1998) Testosterone injection stimulates net protein synthesis but not tissue amino acid transport. American Journal of Physiology - Endocrinology and Metabolism, 275 (5), pp. E864-E871.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectAmino nitrogen uptakeen_UK
dc.subjectFractional breakdown rateen_UK
dc.titleTestosterone injection stimulates net protein synthesis but not tissue amino acid transporten_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Tipton_2002_Testosterone_injection_stimulates_net_protein_synthesis.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleAmerican journal of physiology. Endocrinology and metabolismen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Texasen_UK
dc.contributor.affiliationUniversity of Texasen_UK
dc.contributor.affiliationUniversity of Texasen_UK
dc.contributor.affiliationUniversity of Texasen_UK
dc.contributor.affiliationUniversity of Texasen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorFerrando, Arny A|en_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.authorDoyle, David J|en_UK
local.rioxx.authorPhillips, Stuart M|en_UK
local.rioxx.authorCortiella, Joaquin|en_UK
local.rioxx.authorWolfe, Robert R|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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