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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Evidence for differential photic regulation of pineal melatonin synthesis in teleosts
Author(s): Migaud, Herve
Davie, Andrew
Martinez-Chavez, Carlos Christian
Al‐Khamees, Sammi
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Keywords: circadian axis
pineal gland
Pineal gland
Circadian rhythms
Issue Date: Nov-2007
Date Deposited: 12-May-2009
Citation: Migaud H, Davie A, Martinez-Chavez CC & Al‐Khamees S (2007) Evidence for differential photic regulation of pineal melatonin synthesis in teleosts. Journal of Pineal Research, 43 (4), pp. 327-335.
Abstract: The aim of this study was to compare the circadian control of melatonin production in teleosts. To do so, the effects of ophthalmectomy on circulating melatonin rhythms were studied along with ex vivo pineal culture in six different teleosts. Results strongly suggested that the circadian control of melatonin production could have dramatically changed with at least three different systems being present in teleosts when one considers the photic regulation of pineal melatonin production. First, salmonids presented a decentralized system in which the pineal gland responds directly to light independently of the eyes. Then, in seabass and cod both the eyes and the pineal gland are required to sustain full night-time melatonin production. Finally, a third type of circadian control of melatonin production is proposed in tilapia and catfish in which the pineal gland would not be light sensitive (or only slightly) and required the eyes to perceive light and inhibit melatonin synthesis. Further studies (anatomical, ultrastructural, retinal projections) are needed to confirm these results. Ex vivo experiments indirectly confirmed these results, as while the pineal gland responded normally to day–night rhythms in salmonids, seabass and cod, only very low levels were obtained at night in tilapia and no melatonin could be measured from isolated pineal glands in catfish. Together, these findings suggest that mechanisms involved in the perception of light and the transduction of this signal through the circadian axis has changed in teleosts possibly as a reflection of the photic environment in which they have evolved in.
DOI Link: 10.1111/j.1600-079X.2007.00480.x
Rights: Published in Journal of Pineal Research. Copyright: Blackwell Munksgaard.; The definitive version is available at

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