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Appears in Collections:Faculty of Health Sciences and Sport Systematic Reviews
Peer Review Status: Refereed
Title: Garlic for peripheral arterial occlusive disease
Author(s): Jepson, Ruth
Kleijnen, Jos
Leng, Gillian C
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Citation: Jepson R, Kleijnen J & Leng GC (2008) Garlic for peripheral arterial occlusive disease (Review). Cochrane Database of Systematic Reviews, (3), Art. No.: CD000095.
Issue Date: 2008
Date Deposited: 21-Jan-2013
Publisher: Wiley-Blackwell for The Cochrane Collaboration
Abstract: Background: Commercially available preparations of garlic have been reported to have beneficial effects on some of the risk factors associated with atherosclerosis. Objectives: To assess the effects of garlic (both dried and non-powdered preparations) for the treatment of peripheral arterial occlusive disease. Search methods: We searched the Cochrane Peripheral Vascular Diseases Group trials register, the Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, Issue 4, 2007, AMED, EMBASE, Science Citation Index, abstracts of relevant symposia and reference lists of relevant articles up to November 2007. We also contacted pharmaceutical companies, investigators and experts in garlic therapies. Selection criteria: Randomised trials of garlic therapy in patients with lower limb atherosclerosis were included. The main outcomes were objective measures of progression of underlying atherosclerosis (e.g. ankle pressure measurements, treadmill testing) and subjective measures (e.g. symptom progression). Data collection and analysis: Two review authors (RJ and JK) independently extracted data and assessed trial quality. One author (RJ) contacted investigators to obtain information needed for the review that could not be found in published reports. Main results: One eligible trial with 78 participants was found. Both men and women (aged 40 to 75) were included. The follow-up period was short, 12 weeks only. After twelve weeks of treatment, pain-free walking distance increased from 161 to 207 metres in the group receiving garlic and from 172 to 203 metres in the placebo group. This was not a statistically significant difference. There was no difference in change of systolic or diastolic blood pressure, heart rate, ankle and brachial pressures. No severe side effects were observed and nine patients taking garlic (28%) and four patients taking placebo (12%) complained of a noticeable garlic smell. One further trial was excluded from the review because it did not include any clinical measurements. Authors' conclusions: One small trial of short duration found no statistically significant effect of garlic on walking distance.
Article no.: CD000095
Type: Journal Article
Affiliation: Health Sciences Stirling
Kleijnen Systematic Reviews Ltd
London School of Hygiene and Tropical Medicine

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