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dc.contributor.authorJepson, Ruthen_UK
dc.contributor.authorKleijnen, Josen_UK
dc.contributor.authorLeng, Gillian Cen_UK
dc.description.abstractBackground: Commercially available preparations of garlic have been reported to have beneficial effects on some of the risk factors associated with atherosclerosis. Objectives: To assess the effects of garlic (both dried and non-powdered preparations) for the treatment of peripheral arterial occlusive disease. Search methods: We searched the Cochrane Peripheral Vascular Diseases Group trials register, the Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, Issue 4, 2007, AMED, EMBASE, Science Citation Index, abstracts of relevant symposia and reference lists of relevant articles up to November 2007. We also contacted pharmaceutical companies, investigators and experts in garlic therapies. Selection criteria: Randomised trials of garlic therapy in patients with lower limb atherosclerosis were included. The main outcomes were objective measures of progression of underlying atherosclerosis (e.g. ankle pressure measurements, treadmill testing) and subjective measures (e.g. symptom progression). Data collection and analysis: Two review authors (RJ and JK) independently extracted data and assessed trial quality. One author (RJ) contacted investigators to obtain information needed for the review that could not be found in published reports. Main results: One eligible trial with 78 participants was found. Both men and women (aged 40 to 75) were included. The follow-up period was short, 12 weeks only. After twelve weeks of treatment, pain-free walking distance increased from 161 to 207 metres in the group receiving garlic and from 172 to 203 metres in the placebo group. This was not a statistically significant difference. There was no difference in change of systolic or diastolic blood pressure, heart rate, ankle and brachial pressures. No severe side effects were observed and nine patients taking garlic (28%) and four patients taking placebo (12%) complained of a noticeable garlic smell. One further trial was excluded from the review because it did not include any clinical measurements. Authors' conclusions: One small trial of short duration found no statistically significant effect of garlic on walking distance.en_UK
dc.publisherWiley-Blackwell for The Cochrane Collaborationen_UK
dc.relationJepson R, Kleijnen J & Leng GC (2008) Garlic for peripheral arterial occlusive disease (Review). Cochrane Database of Systematic Reviews, (3), Art. No.: CD000095.
dc.rightsThis review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2008, Issue 3. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review. This is the reference to the original version of this review: Jepson RG, Kleijnen J, Leng GC. Garlic for peripheral arterial occlusive disease. Cochrane Database of Systematic Reviews 1997, Issue 2. Art. No.: CD000095. DOI: 10.1002/14651858.CD000095en_UK
dc.titleGarlic for peripheral arterial occlusive diseaseen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleCochrane Database of Systematic Reviewsen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.description.notesOutput Type: Reviewen_UK
dc.contributor.affiliationHealth Sciences Stirlingen_UK
dc.contributor.affiliationKleijnen Systematic Reviews Ltden_UK
dc.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorJepson, Ruth|0000-0002-9446-445Xen_UK
local.rioxx.authorKleijnen, Jos|en_UK
local.rioxx.authorLeng, Gillian C|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameJepson et al_Cochrane_2008.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Systematic Reviews

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