Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/10330
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dc.contributor.authorBetancor, Monica-
dc.contributor.authorCaballero, Maria Jose-
dc.contributor.authorTerova, Genciana-
dc.contributor.authorCora, Samuela-
dc.contributor.authorSaleh, Reda-
dc.contributor.authorBenitez-Santana, Tibiabin-
dc.contributor.authorBell, J Gordon-
dc.contributor.authorHernandez-Cruz, Carmen Maria-
dc.contributor.authorIzquierdo, Marisol S-
dc.date.accessioned2015-06-09T00:27:13Z-
dc.date.available2015-06-09T00:27:13Z-
dc.date.issued2012-12-
dc.identifier.urihttp://hdl.handle.net/1893/10330-
dc.description.abstractDocosahexaenoic acid (DHA) is an essential fatty acid necessary for many biochemical, cellular and physiological functions in fish. However, high dietary levels of DHA increase free radical injury in sea bass (Dicentrarchus labrax) larvae muscle, even when vitamin E (α-tocopherol, α-TOH) is increased. Therefore, the inclusion of other nutrients with complementary antioxidant functions, such as vitamin C (ascorbic acid, vitC), could further contribute to prevent these lesions. The objective of the present study was to determine the effect of vitC inclusion (3,600 mg/kg) in high DHA (5 % DW) and α-TOH (3,000 mg/kg) microdiets (diets 5/3,000 and 5/3,000 + vitC) in comparison to a control diet (1 % DHA DW and 1,500 mg/kg of α-TOH; diet 1/1,500) on sea bass larvae growth, survival, whole body biochemical composition and thiobarbituric acid reactive substances (TBARS) content, muscle morphology, skeletal deformities and antioxidant enzymes, insulin-like growth factors (IGFs) and myosin expression (MyHC). Larvae fed diet 1/1,500 showed the best performance in terms of total length, incidence of muscular lesions and ossification degree. IGFs gene expression was elevated in 5/3,000 diet larvae, suggesting an increased muscle mitogenesis that was confirmed by the increase in the mRNA copies of MyHC. vitC effectively controlled oxidative damages in muscle, increased α-TOH larval contents and reduced TBARS content and the occurrence of skull deformities. The results of the present study showed the antioxidant synergism between vitamins E and C when high contents of DHA are included in sea bass larvae diets.en_UK
dc.language.isoen-
dc.publisherSpringer-
dc.relationBetancor M, Caballero MJ, Terova G, Cora S, Saleh R, Benitez-Santana T, Bell JG, Hernandez-Cruz CM & Izquierdo MS (2012) Vitamin C Enhances Vitamin E Status and Reduces Oxidative Stress Indicators in Sea Bass Larvae Fed High DHA Microdiets, Lipids, 47 (2), pp. 1193-1207.-
dc.rightsPublisher policy allows this work to be made available in this repository; The original publication is available at www.springerlink.com-
dc.subjectDHAen_UK
dc.subjectVitamin Een_UK
dc.subjectVitamin Cen_UK
dc.subjectMuscle morphologyen_UK
dc.subjectAntioxidant enzymesen_UK
dc.subjectIGFen_UK
dc.subjectMyHCen_UK
dc.titleVitamin C Enhances Vitamin E Status and Reduces Oxidative Stress Indicators in Sea Bass Larvae Fed High DHA Microdietsen_UK
dc.typeJournal Articleen_UK
dc.identifier.doihttp://dx.doi.org/10.1007/s11745-012-3730-x-
dc.citation.jtitleLipids-
dc.citation.issn0024-4201-
dc.citation.volume47-
dc.citation.issue2-
dc.citation.spage1193-
dc.citation.epage1207-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailm.b.betancor@stir.ac.uk-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canaria-
dc.contributor.affiliationUniversity of Insubria, Italy-
dc.contributor.affiliationUniversity of Insubria, Italy-
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canaria-
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canaria-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canaria-
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canaria-
dc.identifier.isi000311396700007-
Appears in Collections:Aquaculture Journal Articles

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