Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/10300
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dc.contributor.authorBlackwood, Douglas Hen_UK
dc.contributor.authorGlabus, Michael Fen_UK
dc.contributor.authorDunan, Julie Ren_UK
dc.contributor.authorO'Carroll, Ronanen_UK
dc.contributor.authorMuir, Walter Jen_UK
dc.contributor.authorEbmeier, Klaus Pen_UK
dc.date.accessioned2013-06-05T23:29:13Z-
dc.date.available2013-06-05T23:29:13Z-
dc.date.issued1999-10en_UK
dc.identifier.urihttp://hdl.handle.net/1893/10300-
dc.description.abstractBACKGROUND Genetic studies in schizophrenia are hampered by the complex heterogeneous clinical phenotype. Biological variables identified as trait markers of risk could clarify the mode of inheritance, define clinical subgroups and provide clues about aetiology. AIMS To use single photon emission computed tomography (SPECT) to compare brain perfusion maps in patients with schizophrenia (n = 19), their asymptomatic 'high-risk' relatives (n = 36) and control subjects (n = 34) and to examine the relationships between imaging, memory and P300 event-related potential. METHOD SPECT, memory tests and P300 recording were carried out. RESULTS In the patients with schizophrenia and their relatives, perfusion was reduced in left inferior prefrontal and anterior cingulate cortex and increased bilaterally in a subcortical region. Perfusion significantly correlated with verbal memory and P300 amplitude in left inferior prefrontal cortex and with P300 latency in anterior cingulate cortex. CONCLUSIONS Medication- and symptom-free relatives had altered regional perfusion intermediate between subjects with schizophrenia and controls. Impaired perfusion, verbal memory and P300 appear to be related traits associated with an increased risk of illness.en_UK
dc.language.isoenen_UK
dc.publisherThe Royal College of Psychiatristsen_UK
dc.relationBlackwood DH, Glabus MF, Dunan JR, O'Carroll R, Muir WJ & Ebmeier KP (1999) Altered cerebral perfusion measured by SPECT in relatives of patients with schizophrenia. Correlations with memory and P300. British Journal of Psychiatry, 175 (4), pp. 357-366. https://doi.org/10.1192/bjp.175.4.357en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectSchizophreniaen_UK
dc.subjectMedicineen_UK
dc.subjectNeurosciencesen_UK
dc.subjectNeurologyen_UK
dc.subjectNeurobiologyen_UK
dc.subjectPsychology, clinicalen_UK
dc.subjectBiomedicineen_UK
dc.subjectNeurosciencesen_UK
dc.titleAltered cerebral perfusion measured by SPECT in relatives of patients with schizophrenia. Correlations with memory and P300en_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Blackwood et al_BJP_1999.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1192/bjp.175.4.357en_UK
dc.citation.jtitleBritish Journal of Psychiatryen_UK
dc.citation.issn1472-1465en_UK
dc.citation.issn0007-1250en_UK
dc.citation.volume175en_UK
dc.citation.issue4en_UK
dc.citation.spage357en_UK
dc.citation.epage366en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailronan.ocarroll@stir.ac.uken_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.identifier.scopusid2-s2.0-0032888785en_UK
dc.identifier.wtid747220en_UK
dc.contributor.orcid0000-0002-5130-291Xen_UK
dcterms.dateAccepted1999-10-31en_UK
dc.date.filedepositdate2012-12-05en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorBlackwood, Douglas H|en_UK
local.rioxx.authorGlabus, Michael F|en_UK
local.rioxx.authorDunan, Julie R|en_UK
local.rioxx.authorO'Carroll, Ronan|0000-0002-5130-291Xen_UK
local.rioxx.authorMuir, Walter J|en_UK
local.rioxx.authorEbmeier, Klaus P|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameBlackwood et al_BJP_1999.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0007-1250en_UK
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