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dc.contributor.authorDezfuli, Bahram Sen_UK
dc.contributor.authorGiari, Luisaen_UK
dc.contributor.authorSimoni, Edien_UK
dc.contributor.authorShinn, Andrewen_UK
dc.contributor.authorManera, Maurizioen_UK
dc.contributor.authorBosi, Giampaoloen_UK
dc.description.abstractHistopathological, ultrastructural and immunohistochemical investigations were conducted on 26 specimens of powan Coregonus lavaretus (L.) from Loch Lomond (Scotland). The hearts of all 26 powan (15 females and 11 males) investigated harboured metacercariae of the digenean trematode Ichthyocotylurus erraticus (Rudolphi, 1809). The vast majority of metacercariae were located either singly or as an aggregation of white cysts on the surface of the bulbus arteriosus. The intensity of infection ranged from 2 to 200 larvae heart-1, although the number of metacercariae found on male powan did not exceed 13. Histochemically, the parasite cyst wall gave a strong positive reaction with periodic acid schiff (PAS) and a faint positive signal with Azan-Mallory stain. All the metacercariae cysts were embedded in a granulomatous proliferation of heart epicardium tissue, forming a reactive fibroconnective capsule around the parasite. The capsule enclosing the parasite (produced by the host's reaction to the parasite) measured 13.57 to 90.20 µm (37.43 ± 3.56) in thickness. Within the capsule wall, eosinophilic granular cells (EGCs), granulocytes, melanocytes and, in some instances, partially degenerated or vacuolated epithelioid cells were observed in close proximity to the cyst wall. Pigment-bearing macrophages were scattered throughout the granulomatous host-tissue reaction and as macrophage aggregates (MAs) within the capsules surrounding parasites. Immunohistochemical tests were applied to infected heart sections using 12 different antisera. Nerve fibres immunoreactive to bombesin, substance P (SP), and atrial natriuretic peptide (ANP) antisera were observed in close proximity to the parasite larvae. The presence of a serotonin-like substance was also observed within host immune-cells surrounding trematode cysts. Large cells of the epicardium were found to be immunoreactive to met-enkephalin and vasoactive intestinal peptide (VIP) antisera but not immunoreactive to anti-protein gene-product 9.5 (PGP9.5) sera.en_UK
dc.publisherInter Researchen_UK
dc.relationDezfuli BS, Giari L, Simoni E, Shinn A, Manera M & Bosi G (2005) Histopathology, ultrastructure and immunohistochemistry of Coregonus lavaretus hearts naturally infected with Ichthyocotylurus erraticus (Trematoda). Diseases of Aquatic Organisms, 66 (3), pp. 245-254.
dc.rightsPublished in Diseases of Aquatic Organisms by Inter-Research. All articles published by Inter-Research journals become open access (IR OA) 5 years after publication. Open Access under Creative Commons licence (CC-BY 3.0):
dc.subjectTrematode infectionen_UK
dc.subjectCoregonus lavaretusen_UK
dc.titleHistopathology, ultrastructure and immunohistochemistry of Coregonus lavaretus hearts naturally infected with Ichthyocotylurus erraticus (Trematoda)en_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleDiseases of Aquatic Organismsen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Ferraraen_UK
dc.contributor.affiliationUniversity of Ferraraen_UK
dc.contributor.affiliationUniversity of Ferraraen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Teramoen_UK
dc.contributor.affiliationUniversity of Milanen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorDezfuli, Bahram S|en_UK
local.rioxx.authorGiari, Luisa|en_UK
local.rioxx.authorSimoni, Edi|en_UK
local.rioxx.authorShinn, Andrew|0000-0002-5434-2685en_UK
local.rioxx.authorManera, Maurizio|en_UK
local.rioxx.authorBosi, Giampaolo|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameDezfuli et al 2005 Ichthyocotylurus.pdfen_UK
Appears in Collections:Aquaculture Journal Articles

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