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dc.contributor.authorEbmeier, Klaus Pen_UK
dc.contributor.authorCavanagh, Jonathan T Oen_UK
dc.contributor.authorMoffoot, Anthony P Ren_UK
dc.contributor.authorGlabus, Michael Fen_UK
dc.contributor.authorO'Carroll, Ronanen_UK
dc.contributor.authorGoodwin, Guy Men_UK
dc.description.abstractBACKGROUND The spontaneous diurnal variation of mood and other symptoms provides a substrate for the examination of the relationship between symptoms and regional brain activation in depression. METHOD Twenty unipolar depressed patients with diurnal variation of mood were examined at 8 a.m. and 8 p.m. with neuropsychological measures, clinical ratings and single photon emission tomography (SPET). Brain perfusion maps were spatially transformed into standard stereotactic space and compared pixel-by-pixel. A parametric (correlational) analysis was used to examine the relationship between symptom severity and brain perfusion, both between and within subjects. RESULTS Global depression severity and an independent 'vital' depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas. In addition there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion. CONCLUSIONS Depressive symptom changes are associated with metabolic changes in the cingulate gyrus and associated paralimbic structures.en_UK
dc.publisherThe Royal College of Psychiatristsen_UK
dc.relationEbmeier KP, Cavanagh JTO, Moffoot APR, Glabus MF, O'Carroll R & Goodwin GM (1997) Cerebral perfusion correlates of depressed mood. British Journal of Psychiatry, 170 (1), pp. 77-81.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectDepression, Mentalen_UK
dc.subjectDepressive Disorder -- therapyen_UK
dc.subjectPrimary Health Care -- methods.en_UK
dc.titleCerebral perfusion correlates of depressed mooden_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Ebmeier et al _BJP_1997.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleBritish Journal of Psychiatryen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorEbmeier, Klaus P|en_UK
local.rioxx.authorCavanagh, Jonathan T O|en_UK
local.rioxx.authorMoffoot, Anthony P R|en_UK
local.rioxx.authorGlabus, Michael F|en_UK
local.rioxx.authorO'Carroll, Ronan|0000-0002-5130-291Xen_UK
local.rioxx.authorGoodwin, Guy M|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameEbmeier et al _BJP_1997.pdfen_UK
Appears in Collections:Psychology Journal Articles

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