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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Masculinization of genetic female Nile tilapia (Oreochromis niloticus) by dietary administration of an aromatase inhibitor during sexual differentiation
Author(s): Kwon, Joon Yeong
Haghpanah, Vahid
Kogson-Hurtado, Luz Mary
McAndrew, Brendan
Penman, David
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Keywords: Sex determination, Genetic
Nile Tilapia
Issue Date: 15-Jun-2000
Date Deposited: 7-Nov-2012
Citation: Kwon JY, Haghpanah V, Kogson-Hurtado LM, McAndrew B & Penman D (2000) Masculinization of genetic female Nile tilapia (Oreochromis niloticus) by dietary administration of an aromatase inhibitor during sexual differentiation. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 287 (1), pp. 46-53.
Abstract: A series of experiments was carried out in which genetically female Nile tilapia (Oreochromis niloticus) fry were treated with Fadrozole, a nonsteroidal aromatase inhibitor (AI), in the diet during the period of sexual differentiation. Batches of tilapia fry treated with AI during the first 30 days following yolk-sac resorption (7-37 days post hatch, dph) showed a dose-dependent increase in the percentage of males from 0 to 200 mg · kg-1. The percentage of males remained approximately constant (92.5-96.0%) from 200 to 500 mg · kg-1. Any continuous 2- or 3-week treatment with 500 mg · kg-1 AI in this 4-week period successfully masculinized the majority of the treated fish (greater than 80%). Treatments of 1 week duration revealed that the most sensitive time to AI lies in the first week (between 7 and 14 dph). Progeny testing of males from AI-treated groups gave results indicating that these were XX males, as expected. These experiments strongly implicate aromatase activity as a key factor in sexual differentiation in the Nile tilapia.
DOI Link: 10.1002/1097-010X(20000615)287:1<46::AID-JEZ6>3.0.CO;2-X
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