|Appears in Collections:||Aquaculture Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Masculinization of genetic female Nile tilapia (Oreochromis niloticus) by dietary administration of an aromatase inhibitor during sexual differentiation|
|Author(s):||Kwon, Joon Yeong|
Kogson-Hurtado, Luz Mary
|Keywords:||Sex determination, Genetic|
|Citation:||Kwon JY, Haghpanah V, Kogson-Hurtado LM, McAndrew B & Penman D (2000) Masculinization of genetic female Nile tilapia (Oreochromis niloticus) by dietary administration of an aromatase inhibitor during sexual differentiation. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 287 (1), pp. 46-53. https://doi.org/10.1002/1097-010X%2820000615%29287%3A1%3C46%3A%3AAID-JEZ6%3E3.0.CO%3B2-X|
|Abstract:||A series of experiments was carried out in which genetically female Nile tilapia (Oreochromis niloticus) fry were treated with Fadrozole, a nonsteroidal aromatase inhibitor (AI), in the diet during the period of sexual differentiation. Batches of tilapia fry treated with AI during the first 30 days following yolk-sac resorption (7-37 days post hatch, dph) showed a dose-dependent increase in the percentage of males from 0 to 200 mg · kg-1. The percentage of males remained approximately constant (92.5-96.0%) from 200 to 500 mg · kg-1. Any continuous 2- or 3-week treatment with 500 mg · kg-1 AI in this 4-week period successfully masculinized the majority of the treated fish (greater than 80%). Treatments of 1 week duration revealed that the most sensitive time to AI lies in the first week (between 7 and 14 dph). Progeny testing of males from AI-treated groups gave results indicating that these were XX males, as expected. These experiments strongly implicate aromatase activity as a key factor in sexual differentiation in the Nile tilapia.|
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