Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/9198
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Quick recovery of orientation after magnetic seizure therapy for major depressive disorder
Authors: Kirov, George
Ebmeier, Klaus P
Scott, Allan I F
Atkins, Maria
Khalid, Najeeb
Carrick, Lucy
Stanfield, Andrew
O'Carroll, Ronan
Husain, Mustafa M
Lisanby, Sarah H
Contact Email: ronan.ocarroll@stir.ac.uk
Issue Date: Aug-2008
Publisher: The Royal College of Psychiatrists
Citation: Kirov G, Ebmeier KP, Scott AIF, Atkins M, Khalid N, Carrick L, Stanfield A, O'Carroll R, Husain MM & Lisanby SH (2008) Quick recovery of orientation after magnetic seizure therapy for major depressive disorder, British Journal of Psychiatry, 193 (2), pp. 152-155.
Abstract: Background - Magnetic seizure therapy, in which seizures are elicited with a high-frequency magnetic field, is under development as a new treatment for major depressive disorder. Its use may be justified if it produces the antidepressant effects of electroconvulsive therapy (ECT), coupled with limited cognitive side-effects. Aims - To evaluate the usefulness of a new 100 Hz magnetic seizure therapy device. Method - We induced seizures with 100 Hz magnetic transcranial stimulation in 11 patients with major depressive disorder during one session of a regular course of ECT. Recovery times after seizures induced by magnetic seizure therapy and ECT were compared. Results - Seizures could be elicited in 10 of the 11 patients. Stimulation over the vertex produced tonic-clonic activity on 9 out of 11 occasions. Stimulation over the prefrontal midpoint elicited seizures on 3 out of 7 occasions. The mean duration of magnetically induced seizures was 31.3 s, ranging from 10 to 86 s. All patients had an exceptionally quick recovery of orientation: mean of 7 min 12 s (s.d.=2 min 7 s, range 4 min 20 s to 9 min 41 s). The recovery times were on average 15 min 35 s shorter with magnetic seizure therapy than with ECT in the same patients (paired-samples t-test: P less than 0.0001). Patients reported feeling less confused after magnetic seizure therapy. Side-effects were confined to myoclonic movements, associated with the use of etomidate. Conclusions - The new 100 Hz magnetic stimulator elicits seizures in the majority of patients when administered over the vertex. Magnetic seizure therapy was associated with shorter recovery times and less confusion following treatment. Subsequent work will be required to assess the safety and effectiveness of magnetic seizure therapy in the treatment of depression.
Type: Journal Article
URI: http://hdl.handle.net/1893/9198
DOI Link: http://dx.doi.org/10.1192/bjp.bp.107.044362
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Cardiff University
Royal Edinburgh Hospital
Royal Edinburgh Hospital
Whitchurch Hospital, Wales
Whitchurch Hospital, Wales
Royal Edinburgh Hospital
Royal Edinburgh Hospital
Psychology
University of Texas Southwestern Medical Center, USA
Columbia University

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