Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7632
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Beneficial Effects of Resistance Exercise on Glycemic Control Are Not Further Improved by Protein Ingestion
Authors: Breen, Leigh
Philp, Andrew
Shaw, Christopher S
Jeukendrup, Asker E
Baar, Keith
Tipton, Kevin
Contact Email: k.d.tipton@stir.ac.uk
Issue Date: 20-Jun-2011
Publisher: Public Library of Science
Citation: Breen L, Philp A, Shaw CS, Jeukendrup AE, Baar K & Tipton K (2011) Beneficial Effects of Resistance Exercise on Glycemic Control Are Not Further Improved by Protein Ingestion, PLoS ONE, 6 (6), p. e20613.
Abstract: Purpose: To investigate the mechanisms underpinning modifications in glucose homeostasis and insulin sensitivity 24 h after a bout of resistance exercise (RE) with or without protein ingestion. Methods: Twenty-four healthy males were assigned to a control (CON; n = 8), exercise (EX; n = 8) or exercise plus protein condition (EX+PRO; n = 8). Muscle biopsy and blood samples were obtained at rest for all groups and immediately post-RE (75% 1RM, 8×10 repetitions of leg-press and extension exercise) for EX and EX+PRO only. At 24 h post-RE (or post-resting biopsy for CON), a further muscle biopsy was obtained. Participants then consumed an oral glucose load (OGTT) containing 2 g of [U-13C] glucose during an infusion of 6, 6-[2H2] glucose. Blood samples were obtained every 10 min for 2 h to determine glucose kinetics. EX+PRO ingested an additional 25 g of intact whey protein with the OGTT. A final biopsy sample was obtained at the end of the OGTT. Results: Fasted plasma glucose and insulin were similar for all groups and were not different immediately post- and 24 h post-RE. Following RE, muscle glycogen was 26±8 and 19±6% lower in EX and EX+PRO, respectively. During OGTT, plasma glucose AUC was lower for EX and EX+PRO (75.1±2.7 and 75.3±2.8 mmol·L-1:120 min, respectively) compared with CON (90.6±4.1 mmol·L-1:120 min). Plasma insulin response was 13±2 and 21±4% lower for EX and CON, respectively, compared with EX+PRO. Glucose disappearance from the circulation was ~12% greater in EX and EX+PRO compared with CON. Basal 24 h post-RE and insulin-stimulated PAS-AS160/TBC1D4 phosphorylation was greater for EX and EX+PRO. Conclusions: Prior RE improves glycemic control and insulin sensitivity through an increase in the rate at which glucose is disposed from the circulation. However, co-ingesting protein during a high-glucose load does not augment this response at 24 h post-exercise in healthy, insulin-sensitive individuals.
Type: Journal Article
URI: http://hdl.handle.net/1893/7632
URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020613
DOI Link: http://dx.doi.org/10.1371/journal.pone.0020613
Rights: Publisher is open-access. Open access publishing allows free access to and distribution of published articles where the author retains copyright of their work by employing a Creative Commons attribution licence. Proper attribution of authorship and correct citation details should be given. Publisher’s policy available from http://www.plos.org/about/open-access/license/.
Affiliation: University of Birmingham
University of California
University of Birmingham
University of Birmingham
University of California, Davis
Sport

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