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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Stimulation of net muscle protein synthesis by whey protein ingestion before and after exercise
Authors: Tipton, Kevin
Elliott, Tabatha A
Cree, Melanie G
Aarsland, Asle A
Sanford, Arthur P
Wolfe, Robert R
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Keywords: muscle protein synthesis
arteriovenous balance
net muscle protein balance
muscle biopsies
Issue Date: Jan-2007
Publisher: The American Physiological Society
Citation: Tipton K, Elliott TA, Cree MG, Aarsland AA, Sanford AP & Wolfe RR (2007) Stimulation of net muscle protein synthesis by whey protein ingestion before and after exercise, American Journal of Physiology - Endocrinology and Metabolism, 292 (1), pp. E71-E76.
Abstract: Timing of nutrient ingestion has been demonstrated to influence the anabolic response of muscle following exercise. Previously, we demonstrated that net amino acid uptake was greater when free essential amino acids plus carbohydrates were ingested before resistance exercise rather than following exercise. However, it is unclear if ingestion of whole proteins before exercise would stimulate a superior response compared with following exercise. This study was designed to examine the response of muscle protein balance to ingestion of whey proteins both before and following resistance exercise. Healthy volunteers were randomly assigned to one of two groups. A solution of whey proteins was consumed either immediately before exercise (PRE; n = 8) or immediately following exercise (POST; n = 9). Each subject performed 10 sets of 8 repetitions of leg extension exercise. Phenylalanine concentrations were measured in femoral arteriovenous samples to determine balance across the leg. Arterial amino acid concentrations were elevated by ∼50%, and net amino acid balance switched from negative to positive following ingestion of proteins at either time. Amino acid uptake was not significantly different between PRE and POST when calculated from the beginning of exercise (67 ± 22 and 27 ± 10 for PRE and POST, respectively) or from the ingestion of each drink (60 ± 17 and 63 ± 15 for PRE and POST, respectively). Thus the response of net muscle protein balance to timing of intact protein ingestion does not respond as does that of the combination of free amino acids and carbohydrate.
Type: Journal Article
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Affiliation: Sport
University of Texas Medical Branch
University of Texas Medical Branch
University of Texas Medical Branch
University of Texas Medical Branch
University of Texas

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