Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7514
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: A 12-year follow-up study of all-cause and cardiovascular mortality among 10,532 people newly diagnosed with Type 2 diabetes in Tayside, Scotland
Author(s): Barnett, Karen N
Ogston, Simon A
McMurdo, Marion E T
Morris, Andrew D
Evans, Josie
Contact Email: josie.evans@stir.ac.uk
Keywords: Cardiovascular mortality
Epidemiology
Mortality
Risk
Type 2 diabetes
Issue Date: Oct-2010
Date Deposited: 20-Aug-2012
Citation: Barnett KN, Ogston SA, McMurdo MET, Morris AD & Evans J (2010) A 12-year follow-up study of all-cause and cardiovascular mortality among 10,532 people newly diagnosed with Type 2 diabetes in Tayside, Scotland. Diabetic Medicine, 27 (10), pp. 1124-1129. https://doi.org/10.1111/j.1464-5491.2010.03075.x
Abstract: Aims: To determine absolute and relative risks of all-cause and cardiovascular mortality among patients newly diagnosed with Type 2 diabetes. Methods: In an observational cohort study using record-linkage databases, based in Tayside, Scotland, UK, we identified newly diagnosed patients with Type 2 diabetes in 1993-2004. We also identified a set of non-diabetic comparators from lists of patients registered with a general practice, individually matched to the diabetic patients by sex, age and deprivation. We followed up patients for mortality and cardiovascular mortality over a 12-year period and calculated hazard ratios using Cox regression. Results: There were 10 532 patients with Type 2 diabetes and 21 056 non-diabetic comparators. Diabetic patients in every age/sex group had higher absolute mortality rates. Even taking deprivation into account, the hazard ratio for mortality was 1.32 (95% CI 1.25-1.40), decreasing to 1.15 (1.09-1.22) after adjusting for pre-existing cardiovascular disease. The hazard ratios for cardiovascular mortality were higher, decreasing from 1.51 (1.37-1.67) to 1.23 (1.11-1.36) after adjusting for pre-existing cardiovascular disease. The hazard ratios decreased with increasing age at diagnosis, although the difference in absolute rate of mortality increased slightly with age. Increased mortality risks were only evident 2 years after diagnosis and increased thereafter. Conclusions: Patients with Type 2 diabetes have an increased risk of all-cause and cardiovascular mortality compared with non-diabetic comparators, although this is not observable immediately after diagnosis. Age at diagnosis and duration of the disease independently affect absolute and relative mortality risk.
DOI Link: 10.1111/j.1464-5491.2010.03075.x
Rights: Publisher policy allows this work to be made available in this repository. Published in Diabetic Medicine by Diabetes UK and Blackwell Publishing. Diabetic Medicine, Volume 27, Issue 10, pages 1124–1129, October 2010. The definitive version is available at www.blackwell-synergy.com, http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2010.03075.x/abstract

Files in This Item:
File Description SizeFormat 
finalmortalitypaper_JE_diabeticmedicine.pdfFulltext - Accepted Version364.65 kBAdobe PDFView/Open
finalmortalitypaper_JE_diabeticmedicine.docFulltext - Accepted Version159 kBUnknownView/Open



This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved https://creativecommons.org/publicdomain/zero/1.0/

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.