Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7514
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dc.contributor.authorBarnett, Karen Nen_UK
dc.contributor.authorOgston, Simon Aen_UK
dc.contributor.authorMcMurdo, Marion E Ten_UK
dc.contributor.authorMorris, Andrew Den_UK
dc.contributor.authorEvans, Josieen_UK
dc.date.accessioned2014-09-12T20:37:45Z-
dc.date.available2014-09-12T20:37:45Z-
dc.date.issued2010-10en_UK
dc.identifier.urihttp://hdl.handle.net/1893/7514-
dc.description.abstractAims: To determine absolute and relative risks of all-cause and cardiovascular mortality among patients newly diagnosed with Type 2 diabetes. Methods: In an observational cohort study using record-linkage databases, based in Tayside, Scotland, UK, we identified newly diagnosed patients with Type 2 diabetes in 1993-2004. We also identified a set of non-diabetic comparators from lists of patients registered with a general practice, individually matched to the diabetic patients by sex, age and deprivation. We followed up patients for mortality and cardiovascular mortality over a 12-year period and calculated hazard ratios using Cox regression. Results: There were 10 532 patients with Type 2 diabetes and 21 056 non-diabetic comparators. Diabetic patients in every age/sex group had higher absolute mortality rates. Even taking deprivation into account, the hazard ratio for mortality was 1.32 (95% CI 1.25-1.40), decreasing to 1.15 (1.09-1.22) after adjusting for pre-existing cardiovascular disease. The hazard ratios for cardiovascular mortality were higher, decreasing from 1.51 (1.37-1.67) to 1.23 (1.11-1.36) after adjusting for pre-existing cardiovascular disease. The hazard ratios decreased with increasing age at diagnosis, although the difference in absolute rate of mortality increased slightly with age. Increased mortality risks were only evident 2 years after diagnosis and increased thereafter. Conclusions: Patients with Type 2 diabetes have an increased risk of all-cause and cardiovascular mortality compared with non-diabetic comparators, although this is not observable immediately after diagnosis. Age at diagnosis and duration of the disease independently affect absolute and relative mortality risk.en_UK
dc.language.isoenen_UK
dc.publisherWiley-Blackwell for Diabetes UKen_UK
dc.relationBarnett KN, Ogston SA, McMurdo MET, Morris AD & Evans J (2010) A 12-year follow-up study of all-cause and cardiovascular mortality among 10,532 people newly diagnosed with Type 2 diabetes in Tayside, Scotland. Diabetic Medicine, 27 (10), pp. 1124-1129. https://doi.org/10.1111/j.1464-5491.2010.03075.xen_UK
dc.rightsPublisher policy allows this work to be made available in this repository. Published in Diabetic Medicine by Diabetes UK and Blackwell Publishing. Diabetic Medicine, Volume 27, Issue 10, pages 1124–1129, October 2010. The definitive version is available at www.blackwell-synergy.com, http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2010.03075.x/abstracten_UK
dc.subjectCardiovascular mortalityen_UK
dc.subjectEpidemiologyen_UK
dc.subjectMortalityen_UK
dc.subjectRisken_UK
dc.subjectType 2 diabetesen_UK
dc.titleA 12-year follow-up study of all-cause and cardiovascular mortality among 10,532 people newly diagnosed with Type 2 diabetes in Tayside, Scotlanden_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1111/j.1464-5491.2010.03075.xen_UK
dc.citation.jtitleDiabetic Medicineen_UK
dc.citation.issn1464-5491en_UK
dc.citation.issn0742-3071en_UK
dc.citation.volume27en_UK
dc.citation.issue10en_UK
dc.citation.spage1124en_UK
dc.citation.epage1129en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailjosie.evans@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.identifier.isiWOS:000283164500004en_UK
dc.identifier.scopusid2-s2.0-77956798223en_UK
dc.identifier.wtid781760en_UK
dc.contributor.orcid0000-0001-6672-7876en_UK
dcterms.dateAccepted2010-10-31en_UK
dc.date.filedepositdate2012-08-20en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorBarnett, Karen N|en_UK
local.rioxx.authorOgston, Simon A|en_UK
local.rioxx.authorMcMurdo, Marion E T|en_UK
local.rioxx.authorMorris, Andrew D|en_UK
local.rioxx.authorEvans, Josie|0000-0001-6672-7876en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2012-08-20en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2012-08-20|en_UK
local.rioxx.filenamefinalmortalitypaper_JE_diabeticmedicine.pdfen_UK
local.rioxx.filecount2en_UK
local.rioxx.source0742-3071en_UK
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