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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/34585
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dc.contributor.authorLim, Jensonen_UK
dc.date.accessioned2022-10-13T00:01:37Z-
dc.date.available2022-10-13T00:01:37Z-
dc.date.issued2022-10en_UK
dc.identifier.other103954en_UK
dc.identifier.urihttp://hdl.handle.net/1893/34585-
dc.description.abstractPer-/Poly- fluoroalkyl substances represent emerging persistent organic pollutants. Their toxic effects can be broad, yet little attention has been given to organisms at the microscale. To address this knowledge shortfall, the unicellular eukaryote Tetrahymena pyriformis was exposed to increasing concentrations (0 - 5000 μM) of PFOA/PFOS and monitored for cellular motility, division and function (i.e., phagocytosis), reactive oxygen species generation and total protein levels. Both PFOA/PFOS exposure had negative impacts on T. pyriformis, including reduced motility, delayed cell division and oxidative imbalance, with each chemical having distinct toxicological profiles. T. pyriformis represents a promising candidate for assessing the biological effects these emerging anthropogenically-derived contaminants in a freshwater setting.en_UK
dc.language.isoenen_UK
dc.publisherElsevier BVen_UK
dc.relationLim J (2022) Broad toxicological effects of Per-/Poly- fluoroalkyl substances (PFAS) on the unicellular eukaryote, Tetrahymena pyriformis. Environmental Toxicology and Pharmacology, 95, Art. No.: 103954. https://doi.org/10.1016/j.etap.2022.103954en_UK
dc.rightsThis is an open access article distributed under the terms of the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectTetrahymenaen_UK
dc.subjectPerfluorooctanoic acid (PFOA)en_UK
dc.subjectPerfluorooctanesulfonic acid (PFOS)en_UK
dc.subjectphagocytosisen_UK
dc.subjectcell divisionen_UK
dc.subjectreactive oxygen speciesen_UK
dc.titleBroad toxicological effects of Per-/Poly- fluoroalkyl substances (PFAS) on the unicellular eukaryote, Tetrahymena pyriformisen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.etap.2022.103954en_UK
dc.identifier.pmid35948183en_UK
dc.citation.jtitleEnvironmental Toxicology and Pharmacologyen_UK
dc.citation.issn1382-6689en_UK
dc.citation.volume95en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderThe Carnegie Trusten_UK
dc.author.emailjenson.lim@stir.ac.uken_UK
dc.citation.date07/08/2022en_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.identifier.scopusid2-s2.0-85136509073en_UK
dc.identifier.wtid1832535en_UK
dc.contributor.orcid0000-0001-7417-356Xen_UK
dc.date.accepted2022-08-06en_UK
dcterms.dateAccepted2022-08-06en_UK
dc.date.filedepositdate2022-10-12en_UK
dc.relation.funderprojectEvaluating the impact of chronic exposure to low dose ionising radiation on immunityen_UK
dc.relation.funderrefRIG008296en_UK
dc.subject.tagEnvironmental/medical history: pollutionen_UK
dc.subject.tagEnvironment and human healthen_UK
dc.subject.tagWater Qualityen_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorLim, Jenson|0000-0001-7417-356Xen_UK
local.rioxx.projectRIG008296|The Carnegie Trust|en_UK
local.rioxx.freetoreaddate2022-10-12en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2022-10-12|en_UK
local.rioxx.filename1-s2.0-S1382668922001478-main.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1382-6689en_UK
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