Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/33090
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dc.contributor.authorArgyropoulos, Georgios P Den_UK
dc.contributor.authorLoane, Clareen_UK
dc.contributor.authorRoca-Fernandez, Adrianaen_UK
dc.contributor.authorLage-Martinez, Carmenen_UK
dc.contributor.authorGurau, Oanaen_UK
dc.contributor.authorIrani, Sarosh Ren_UK
dc.contributor.authorButler, Christopher Ren_UK
dc.date.accessioned2021-08-17T00:03:49Z-
dc.date.available2021-08-17T00:03:49Z-
dc.date.issued2019-07-08en_UK
dc.identifier.othere46156en_UK
dc.identifier.urihttp://hdl.handle.net/1893/33090-
dc.description.abstractPatients with hippocampal amnesia play a central role in memory neuroscience but the neural underpinnings of amnesia are hotly debated. We hypothesized that focal hippocampal damage is associated with changes across the extended hippocampal system and that these, rather than hippocampal atrophy per se, would explain variability in memory between patients. We assessed this hypothesis in a uniquely large cohort of patients (n=38) after autoimmune limbic encephalitis, a syndrome associated with focal structural hippocampal pathology. These patients showed impaired recall, recognition and maintenance of new information, and remote autobiographical amnesia. Besides hippocampal atrophy, we observed correlatively reduced thalamic and entorhinal cortical volume, resting-state inter-hippocampal connectivity and activity in posteromedial cortex. Associations of hippocampal volume with recall, recognition, and remote memory were fully mediated by wider network abnormalities, and were only direct in forgetting. Network abnormalities may explain the variability across studies of amnesia and speak to debates in memory neuroscience.en_UK
dc.language.isoenen_UK
dc.publishereLife Sciences Publicationsen_UK
dc.relationArgyropoulos GPD, Loane C, Roca-Fernandez A, Lage-Martinez C, Gurau O, Irani SR & Butler CR (2019) Network-wide abnormalities explain memory variability in hippocampal amnesia. eLife, 8, Art. No.: e46156. https://doi.org/10.7554/eLife.46156en_UK
dc.rights© 2019, Argyropoulos et al. This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.titleNetwork-wide abnormalities explain memory variability in hippocampal amnesiaen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.7554/eLife.46156en_UK
dc.identifier.pmid31282861en_UK
dc.citation.jtitleeLifeen_UK
dc.citation.issn2050-084Xen_UK
dc.citation.volume8en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.citation.date08/07/2019en_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.identifier.isiWOS:000476476700001en_UK
dc.identifier.scopusid2-s2.0-85070055281en_UK
dc.identifier.wtid1630009en_UK
dc.contributor.orcid0000-0001-8267-6861en_UK
dc.contributor.orcid0000-0001-9279-1185en_UK
dc.contributor.orcid0000-0002-7667-9748en_UK
dc.date.accepted2019-07-05en_UK
dcterms.dateAccepted2019-07-05en_UK
dc.date.filedepositdate2021-08-16en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorArgyropoulos, Georgios P D|0000-0001-8267-6861en_UK
local.rioxx.authorLoane, Clare|0000-0001-9279-1185en_UK
local.rioxx.authorRoca-Fernandez, Adriana|en_UK
local.rioxx.authorLage-Martinez, Carmen|en_UK
local.rioxx.authorGurau, Oana|en_UK
local.rioxx.authorIrani, Sarosh R|0000-0002-7667-9748en_UK
local.rioxx.authorButler, Christopher R|en_UK
local.rioxx.projectProject ID unknown|Medical Research Council|http://dx.doi.org/10.13039/501100000265en_UK
local.rioxx.freetoreaddate2021-08-16en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2021-08-16|en_UK
local.rioxx.filenameelife-46156-v2.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source2050-084Xen_UK
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