Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2840

Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle
Authors: Cahusac, Peter
Contact Email: p.m.b.cahusac@stir.ac.uk
Keywords: mechanogated channels
capsazepine
camphor
cinnamaldehyde
capsaicin
ruthenium red
icilin
tetraethylammonium
Issue Date: Dec-2009
Publisher: Wiley-Blackwell / Peripheral Nerve Society
Citation: Cahusac P (2009) Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle, Journal of the Peripheral Nervous System, 14 (4), pp. 300-309.
Abstract: The possible functional role of transient receptor potential (TRP) channels was investigated by testing various TRP agonists and antagonists in an isolated rat sinus hair follicle preparation. Extracellular recordings from slowly adapting type II mechanoreceptor units were made. The antagonist capsazepine depressed spontaneous and mechanically evoked activity, with an IC50 of 82 μM. In one- third of units, capsazepine caused a selective depression of mechanically evoked firing, such that the existing spontaneous firing was interrupted by an absence of activity during the mechanical stimulus. The broad spectrum TRP blocker ruthenium red (30 μM) had inconsistent effects, although in some units a delayed onset (following wash) bursting and paroxysmal firing ensued. The agonist icilin (50–100 μM) had an excitatory effect on spontaneous firing, and (-)-menthol (200 μM) had inconsistent effects. Cinnamaldehyde (1–2 mM) depressed all types of activity equally, mechanically evoked and spontaneous. Camphor (0.5–2 mM) also depressed all types of activity, although it had a preferential effect on spontaneous activity. Capsaicin (1–10 μM) and allyl isothiocyanate (50–100 μM) had no clear effects. These results rule out any role for TRPA1 and TRPV1 channels in mechanotransduction processes of slowly adapting type II m
Type: Journal Article
URI: http://hdl.handle.net/1893/2840
DOI Link: http://dx.doi.org/10.1111/j.1529-8027.2009.00242.x
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Psychology

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