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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Developing and validating a theoretical measure of modifiable influences on hormonal therapy medication taking behaviour in women with breast cancer
Authors: Cahir, Catriona
Dombrowski, Stephan U
Kennedy, M John
Sharp, Linda
Bennett, Kathleen E
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Keywords: Theoretical Domains Framework
medication taking behaviour
breast cancer
hormonal therapy
Issue Date: 2017
Citation: Cahir C, Dombrowski SU, Kennedy MJ, Sharp L & Bennett KE (2017) Developing and validating a theoretical measure of modifiable influences on hormonal therapy medication taking behaviour in women with breast cancer, Psychology and Health, 32 (10), pp. 1308-1326.
Abstract: Objective: Taking adjuvant hormonal therapy for 5-10 years is recommended to prevent breast cancer recurrence in those with estrogen positive disease. Despite proven clinical efficacy many women do not take their hormonal therapy as prescribed. This study reports the development and initial validation of a questionnaire measuring the behavioural determinants of hormonal therapy medication taking behaviour (MTB) based on the Theoretical Domains Framework (TDF).  Design: Women with Stage I-III breast cancer (N=223) completed the questionnaire based on the TDF. The TDF is an integrative framework consisting of 14 domains of behaviour change determinants to inform intervention design.  Main outcome measures: Items were developed from previous research, in-depth patient interviews and consultation with health professionals. Confirmatory factor analysis (CFA) was undertaken to generate the model of best fit.  Results: The final questionnaire consisted of 8 domains and CFA produced a reasonable fit (χ2(810)=942, p < 0.001; RMSEA = 0.03 ; CFI = 0.93 and WRMR=0.91) as well as internal consistency (r=0.16 to 0.64). There were adequate levels of discriminant validity for the majority of the domains.  Conclusions: A TDF based measure of the behavioural determinants of MTB was developed. Further research is needed to confirm the reliability and validity of this measure.
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