Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2456
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging
Authors: Sexton, Claire E
Mackay, Clare E
Lonie, Jane A
Bastin, Mark E
Terriere, Emma
O'Carroll, Ronan
Ebmeier, Klaus P
Contact Email: reo1@stir.ac.uk
Keywords: Dementia
Neuropsychology
Voxel based morphometry
Diffusion tensor imaging
Issue Date: 30-Oct-2010
Publisher: Elsevier
Citation: Sexton CE, Mackay CE, Lonie JA, Bastin ME, Terriere E, O'Carroll R & Ebmeier KP (2010) MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging, Psychiatry Research: Neuroimaging, 184 (1), pp. 57-62.
Abstract: Episodic memory is a core feature of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Impaired episodic memory in AD results from the dysfunction of an integrated network and involves both gray and white matter pathologies. We explored the neural correlates of episodic memory in AD, MCI and healthy aging by correlating a measure of episodic memory with hippocampal volume and fractional anisotropy (FA) and mean diffusivity (MD) of the cingulum and fornix. Episodic memory was associated with hippocampal volume and MD of the cingulum and fornix. In contrast, there were fewer significant associations between episodic memory and FA. These findings support a relationship between episodic memory and hippocampal circuitry, and suggest that MD is a more sensitive marker of decreased white matter integrity in the study of AD and MCI than FA. Furthermore, MD was significantly associated with hippocampal volume, indicating that white matter pathology is not completely independent of gray matter pathology. However, the pattern of diffusivity differences in AD and MCI implies a more complex pathology than simply Wallerian degeneration.
Type: Journal Article
URI: http://hdl.handle.net/1893/2456
DOI Link: http://dx.doi.org/10.1016/j.pscychresns.2010.07.005
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Oxford
University of Oxford
University of Edinburgh
University of Edinburgh
University of Edinburgh
Psychology
University of Edinburgh

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