Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24461
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Tomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosis
Authors: Martin-Pozuelo, Gala
Gonzalez-Barrio, Rocio
Barbera, Gonzalo
Albalat, Amaya
Garcia-Alonso, Javier
Mullen, William
Mischak, Harald
Periago, Maria Jesus
Contact Email: amaya.albalat@stir.ac.uk
Keywords: non-alcoholic fatty liver disease (NAFLD)
tomato
biomarkers
peptidome
proteome
urine
capillary electrophoresis coupled to a mass spectrometer (CE-MS)
diagnosis
liver
Issue Date: Oct-2016
Citation: Martin-Pozuelo G, Gonzalez-Barrio R, Barbera G, Albalat A, Garcia-Alonso J, Mullen W, Mischak H & Periago MJ (2016) Tomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosis, International Journal of Molecular Sciences, 17 (11), Art. No.: 1789.
Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, with a high prevalence, and has been shown to increase the risk of type 2 diabetes, cardiovascular disease (CVD), etc. Tomato products contain several natural antioxidants, including lycopene—which has displayed a preventive effect on the development of steatosis and CVD. Accordingly, the aim of the present work was to evaluate the effect of tomato juice consumption on the urinary peptide profile in rats with NAFLD induced by an atherogenic diet and to identify potential peptide biomarkers for diagnosis. Urine samples, collected weekly for four weeks, were analyzed by capillary electrophoresis (CE) coupled to a mass spectrometer (MS). A partial least squares-discriminant analysis (PLS-DA) was carried out to explore the association between differential peptides and treatments. Among the 888 peptides initially identified, a total of 55 were obtained as potential biomarkers. Rats with steatosis after tomato juice intake showed a profile intermediate between that of healthy rats and that of rats with induced hepatic steatosis. Accordingly, tomato products could be considered as a dietary strategy for the impairment of NAFLD, although further research should be carried out to develop a specific biomarkers panel for NAFLD.
DOI Link: http://dx.doi.org/10.3390/ijms17111789
Rights: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). Martín-Pozuelo, G.; González-Barrio, R.; Barberá, G.G.; Albalat, A.; García-Alonso, J.; Mullen, W.; Mischak, H.; Periago, M.J. Tomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosis. Int. J. Mol. Sci. 2016, 17, 1789.

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