Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24461
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dc.contributor.authorMartin-Pozuelo, Galaen_UK
dc.contributor.authorGonzalez-Barrio, Rocioen_UK
dc.contributor.authorBarbera, Gonzaloen_UK
dc.contributor.authorAlbalat, Amayaen_UK
dc.contributor.authorGarcia-Alonso, Javieren_UK
dc.contributor.authorMullen, Williamen_UK
dc.contributor.authorMischak, Haralden_UK
dc.contributor.authorPeriago, Maria Jesusen_UK
dc.date.accessioned2017-06-14T23:51:23Z-
dc.date.available2017-06-14T23:51:23Z-
dc.date.issued2016-10en_UK
dc.identifier.other1789en_UK
dc.identifier.urihttp://hdl.handle.net/1893/24461-
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, with a high prevalence, and has been shown to increase the risk of type 2 diabetes, cardiovascular disease (CVD), etc. Tomato products contain several natural antioxidants, including lycopene—which has displayed a preventive effect on the development of steatosis and CVD. Accordingly, the aim of the present work was to evaluate the effect of tomato juice consumption on the urinary peptide profile in rats with NAFLD induced by an atherogenic diet and to identify potential peptide biomarkers for diagnosis. Urine samples, collected weekly for four weeks, were analyzed by capillary electrophoresis (CE) coupled to a mass spectrometer (MS). A partial least squares-discriminant analysis (PLS-DA) was carried out to explore the association between differential peptides and treatments. Among the 888 peptides initially identified, a total of 55 were obtained as potential biomarkers. Rats with steatosis after tomato juice intake showed a profile intermediate between that of healthy rats and that of rats with induced hepatic steatosis. Accordingly, tomato products could be considered as a dietary strategy for the impairment of NAFLD, although further research should be carried out to develop a specific biomarkers panel for NAFLD.en_UK
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.relationMartin-Pozuelo G, Gonzalez-Barrio R, Barbera G, Albalat A, Garcia-Alonso J, Mullen W, Mischak H & Periago MJ (2016) Tomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosis. International Journal of Molecular Sciences, 17 (11), Art. No.: 1789. https://doi.org/10.3390/ijms17111789en_UK
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). Martín-Pozuelo, G.; González-Barrio, R.; Barberá, G.G.; Albalat, A.; García-Alonso, J.; Mullen, W.; Mischak, H.; Periago, M.J. Tomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosis. Int. J. Mol. Sci. 2016, 17, 1789.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectnon-alcoholic fatty liver disease (NAFLD)en_UK
dc.subjecttomatoen_UK
dc.subjectbiomarkersen_UK
dc.subjectpeptidomeen_UK
dc.subjectproteomeen_UK
dc.subjecturineen_UK
dc.subjectcapillary electrophoresis coupled to a mass spectrometer (CE-MS)en_UK
dc.subjectdiagnosisen_UK
dc.subjectliveren_UK
dc.titleTomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosisen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.3390/ijms17111789en_UK
dc.citation.jtitleInternational Journal of Molecular Sciencesen_UK
dc.citation.issn1422-0067en_UK
dc.citation.issn1661-6596en_UK
dc.citation.volume17en_UK
dc.citation.issue11en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailamaya.albalat@stir.ac.uken_UK
dc.citation.date26/10/2016en_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationSpanish National Research Council (CSIC)en_UK
dc.contributor.affiliationComplex Systems - LEGACYen_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.identifier.isiWOS:000388809600023en_UK
dc.identifier.scopusid2-s2.0-84994060894en_UK
dc.identifier.wtid545835en_UK
dc.contributor.orcid0000-0002-8606-2995en_UK
dc.date.accepted2016-10-11en_UK
dcterms.dateAccepted2016-10-11en_UK
dc.date.filedepositdate2016-10-27en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMartin-Pozuelo, Gala|en_UK
local.rioxx.authorGonzalez-Barrio, Rocio|en_UK
local.rioxx.authorBarbera, Gonzalo|en_UK
local.rioxx.authorAlbalat, Amaya|0000-0002-8606-2995en_UK
local.rioxx.authorGarcia-Alonso, Javier|en_UK
local.rioxx.authorMullen, William|en_UK
local.rioxx.authorMischak, Harald|en_UK
local.rioxx.authorPeriago, Maria Jesus|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2016-10-27en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2016-10-27|en_UK
local.rioxx.filenameMartin-Pozuelo-etal-IJMS-2016.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1661-6596en_UK
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