Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2389
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Overactivation of fear systems to neutral faces in schizophrenia
Authors: Hall, Jeremy
Whalley, Heather C
McKirdy, James W
Romaniuk, Liana
McGonigle, David
McIntosh, Andrew M
Baig, Ben J
Gountouna, Viktoria-Eleni
Job, Dominic E
Donaldson, David
Sprengelmeyer, Reiner
Young, Andrew W
Johnstone, Eve C
Lawrie, Stephen M
Contact Email: did1@stir.ac.uk
Keywords: Amygdala
emotion
face
fear
fMRI
schizophrenia
Issue Date: 1-Jul-2008
Publisher: Elsevier / Society of Biological Psychiatry
Citation: Hall J, Whalley HC, McKirdy JW, Romaniuk L, McGonigle D, McIntosh AM, Baig BJ, Gountouna V, Job DE, Donaldson D, Sprengelmeyer R, Young AW, Johnstone EC & Lawrie SM (2008) Overactivation of fear systems to neutral faces in schizophrenia, Biological Psychiatry, 64 (1), pp. 70-73.
Abstract: Background The amygdala plays a central role in detecting and responding to fear-related stimuli. A number of recent studies have reported decreased amygdala activation in schizophrenia to emotional stimuli (such as fearful faces) compared with matched neutral stimuli (such as neutral faces). We investigated whether the apparent decrease in amygdala activation in schizophrenia could actually derive from increased amygdala activation to the neutral comparator stimuli. Methods Nineteen patients with schizophrenia and 24 matched control participants viewed pictures of faces with either fearful or neutral facial expressions, and a baseline condition, during functional magnetic resonance imaging scanning. Results Patients with schizophrenia showed a relative decrease in amygdala activation to fearful faces compared with neutral faces. However, this difference resulted from an increase in amygdala activation to the neutral faces in patients with schizophrenia, not from a decreased response to the fearful faces. Conclusions Patients with schizophrenia show an increased response of the amygdala to neutral faces. This is sufficient to explain their apparent deficit in amygdala activation to fearful faces compared with neutral faces. The inappropriate activation of neural systems involved in fear to otherwise neutral stimuli may contribute to the development of psychotic symptoms in schizophrenia.
Type: Journal Article
URI: http://hdl.handle.net/1893/2389
URL: http://www.sciencedirect.com/science/journal/00063223
DOI Link: http://dx.doi.org/10.1016/j.biopsych.2007.12.014
Rights: Published in Biological Psychiatry by Elsevier / Society of Biological Psychiatry.
Affiliation: University of Edinburgh
University of Edinburgh
University of Edinburgh
University of Edinburgh
Cardiff University
University of Edinburgh
University of Edinburgh
University of Edinburgh
University of Edinburgh
Psychology
University of St Andrews
University of York
University of Edinburgh
University of Edinburgh

Files in This Item:
File Description SizeFormat 
Donaldson7.pdf1.07 MBAdobe PDFView/Open


This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.