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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men
Authors: McGlory, Chris
Wardle, Sophie
Macnaughton, Lindsay S
Witard, Oliver
Scott, Fraser
Dick, James R
Bell, J Gordon
Phillips, Stuart M
Galloway, S D
Hamilton, David Lee
Tipton, Kevin
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Issue Date: 22-Mar-2016
Publisher: Wiley-Blackwell for the American Physiological Society
Citation: McGlory C, Wardle S, Macnaughton LS, Witard O, Scott F, Dick JR, Bell JG, Phillips SM, Galloway SD, Hamilton DL & Tipton K (2016) Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men, Physiological Reports, 4 (6), Art. No.: e12715.
Abstract: Fish oil (FO) supplementation potentiates muscle protein synthesis (MPS) in response to a hyperaminoacidemic–hyperinsulinemic infusion. Whether FO supplementation potentiates MPS in response to protein ingestion or when protein ingestion is combined with resistance exercise (RE) remains unknown. In a randomized, parallel group design, 20 healthy males were randomized to receive 5g/day of either FO or coconut oil control (CO) for 8weeks. After supplementation, participants performed a bout of unilateral RE followed by ingestion of 30g of whey protein. Skeletal muscle biopsies were obtained before and after supplementation for assessment of muscle lipid composition and relevant protein kinase activities. Infusion of l‐[ring‐13C6] phenylalanine was used to measure basal myofibrillar MPS at rest (REST), in a nonexercised leg following protein ingestion (FED) and following RE and protein ingestion (FEDEX). MPS was significantly elevated above REST during FEDEX in both the FO and CO groups, but there was no effect of supplementation. There was a significant increase in MPS in both groups above REST during FED but no effect of supplementation. Supplementation significantly decreased panPKB activity at REST in the FO group but not the CO group. There was a significant increase from REST at post‐RE for PKB and AMPKα2 activity in the CO group but not in the FO group. In FEDEX, there was a significant increase in p70S6K1 activity from REST at 3h in the CO group only. These data highlight that 8weeks of FO supplementation alters kinase signaling activity in response to RE plus protein ingestion without influencing MPS.
Type: Journal Article
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Rights: © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Affiliation: McMaster University
University of Stirling
University of Stirling
McMaster University

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