Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/23012
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dc.contributor.authorMcGlory, Chrisen_UK
dc.contributor.authorWardle, Sophieen_UK
dc.contributor.authorMacnaughton, Lindsay Sen_UK
dc.contributor.authorWitard, Oliveren_UK
dc.contributor.authorScott, Fraseren_UK
dc.contributor.authorDick, James Ren_UK
dc.contributor.authorBell, J Gordonen_UK
dc.contributor.authorPhillips, Stuart Men_UK
dc.contributor.authorGalloway, S Den_UK
dc.contributor.authorHamilton, David Leeen_UK
dc.contributor.authorTipton, Kevinen_UK
dc.date.accessioned2017-03-21T22:28:51Z-
dc.date.available2017-03-21T22:28:51Z-
dc.date.issued2016-03-22en_UK
dc.identifier.othere12715en_UK
dc.identifier.urihttp://hdl.handle.net/1893/23012-
dc.description.abstractFish oil (FO) supplementation potentiates muscle protein synthesis (MPS) in response to a hyperaminoacidemic–hyperinsulinemic infusion. Whether FO supplementation potentiates MPS in response to protein ingestion or when protein ingestion is combined with resistance exercise (RE) remains unknown. In a randomized, parallel group design, 20 healthy males were randomized to receive 5g/day of either FO or coconut oil control (CO) for 8weeks. After supplementation, participants performed a bout of unilateral RE followed by ingestion of 30g of whey protein. Skeletal muscle biopsies were obtained before and after supplementation for assessment of muscle lipid composition and relevant protein kinase activities. Infusion of l‐[ring‐13C6] phenylalanine was used to measure basal myofibrillar MPS at rest (REST), in a nonexercised leg following protein ingestion (FED) and following RE and protein ingestion (FEDEX). MPS was significantly elevated above REST during FEDEX in both the FO and CO groups, but there was no effect of supplementation. There was a significant increase in MPS in both groups above REST during FED but no effect of supplementation. Supplementation significantly decreased panPKB activity at REST in the FO group but not the CO group. There was a significant increase from REST at post‐RE for PKB and AMPKα2 activity in the CO group but not in the FO group. In FEDEX, there was a significant increase in p70S6K1 activity from REST at 3h in the CO group only. These data highlight that 8weeks of FO supplementation alters kinase signaling activity in response to RE plus protein ingestion without influencing MPS.en_UK
dc.language.isoenen_UK
dc.publisherWiley-Blackwell for the American Physiological Societyen_UK
dc.relationMcGlory C, Wardle S, Macnaughton LS, Witard O, Scott F, Dick JR, Bell JG, Phillips SM, Galloway SD, Hamilton DL & Tipton K (2016) Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men. Physiological Reports, 4 (6), Art. No.: e12715. https://doi.org/10.14814/phy2.12715en_UK
dc.rights© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.titleFish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young menen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.14814/phy2.12715en_UK
dc.identifier.pmid27009278en_UK
dc.citation.jtitlePhysiological Reportsen_UK
dc.citation.issn2051-817Xen_UK
dc.citation.volume4en_UK
dc.citation.issue6en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailk.d.tipton@stir.ac.uken_UK
dc.citation.date22/03/2016en_UK
dc.contributor.affiliationMcMaster Universityen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationMcMaster Universityen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationSporten_UK
dc.identifier.isiWOS:000380239400005en_UK
dc.identifier.scopusid2-s2.0-84962110294en_UK
dc.identifier.wtid575440en_UK
dc.contributor.orcid0000-0002-5875-8397en_UK
dc.contributor.orcid0000-0002-1622-3044en_UK
dc.contributor.orcid0000-0002-5620-4788en_UK
dc.contributor.orcid0000-0002-6545-8122en_UK
dc.date.accepted2016-01-28en_UK
dcterms.dateAccepted2016-01-28en_UK
dc.date.filedepositdate2016-03-29en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMcGlory, Chris|en_UK
local.rioxx.authorWardle, Sophie|en_UK
local.rioxx.authorMacnaughton, Lindsay S|en_UK
local.rioxx.authorWitard, Oliver|0000-0002-5875-8397en_UK
local.rioxx.authorScott, Fraser|en_UK
local.rioxx.authorDick, James R|en_UK
local.rioxx.authorBell, J Gordon|en_UK
local.rioxx.authorPhillips, Stuart M|en_UK
local.rioxx.authorGalloway, S D|0000-0002-1622-3044en_UK
local.rioxx.authorHamilton, David Lee|0000-0002-5620-4788en_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2016-03-29en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2016-03-29|en_UK
local.rioxx.filenamemcglory 16 FO RE MPS PhysRep.pdfen_UK
local.rioxx.filecount1en_UK
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