Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22313
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: The Postsubiculum and Spatial Learning: The Role of Postsubicular Synaptic Activity and Synaptic Plasticity in Hippocampal Place Cell, Object, and Object-Location Memory
Authors: Bett, David
Stevenson, Cassie H
Shires, Kate L
Smith, Matthew T
Martin, Steven J
Dudchenko, Paul
Wood, Emma R
Contact Email: p.a.dudchenko@stir.ac.uk
Issue Date: 17-Apr-2013
Publisher: Society for Neuroscience
Citation: Bett D, Stevenson CH, Shires KL, Smith MT, Martin SJ, Dudchenko P & Wood ER (2013) The Postsubiculum and Spatial Learning: The Role of Postsubicular Synaptic Activity and Synaptic Plasticity in Hippocampal Place Cell, Object, and Object-Location Memory, Journal of Neuroscience, 33 (16), pp. 6928-6943.
Abstract: Visual landmarks exert stimulus control over spatial behavior and the spatially tuned firing of place, head-direction, and grid cells in the rodent. However, the neural site of convergence for representations of landmarks and representations of space has yet to be identified. A potential site of plasticity underlying associations with landmarks is the postsubiculum. To test this, we blocked glutamatergic transmission in the rat postsubiculum with CNQX, or NMDA receptor-dependent plasticity with d-AP5. These infusions were sufficient to block evoked potentials from the lateral dorsal thalamus and long-term depression following tetanization of this input to the postsubiculum, respectively. In a second experiment, CNQX disrupted the stability of rat hippocampal place cell fields in a familiar environment. In a novel environment, blockade of plasticity with d-AP5 in the postsubiculum did not block the formation of a stable place field map following a 6 h delay. In a final behavioral experiment, postsubicular infusions of both compounds blocked object-location memory in the rat, but did not affect object recognition memory. These results suggest that the postsubiculum is necessary for the recognition of familiar environments, and that NMDA receptor-dependent plasticity in the postsubiculum is required for the formation of new object-place associations that support recognition memory. However, plasticity in the postsubiculum is not necessary for the formation of new spatial maps.
Type: Journal Article
URI: http://hdl.handle.net/1893/22313
DOI Link: http://dx.doi.org/10.1523/JNEUROSCI.5476-12.2013
Rights: Publisher policy allows this work to be made available in this repository. Published in Journal of Neuroscience, 2013, 33 (16), pp. 6928-6943 by Society for Neuroscience. The original publication is available at: http://www.jneurosci.org/content/33/16/6928
Affiliation: Psychology
University of Edinburgh
University of Edinburgh
University of Edinburgh
University of Edinburgh
Psychology
University of Edinburgh

Files in This Item:
File Description SizeFormat 
Bett et al_Journal of Neuroscience_2013.full.pdf2.92 MBAdobe PDFView/Open


This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.