Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22266
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Neuromodulation of associative and organizational plasticity across the life span: Empirical evidence and neurocomputational modeling
Authors: Li, Shu-Chen
Brehmer, Yvonne
Shing, Yee Lee
Werkle-Bergner, Markus
Lindenberger, Ulman
Contact Email: yee.shing@stir.ac.uk
Keywords: Neural plasticity
Memory plasticity
Neuromodulation
Neural networks
Signal-to-noise
Neuroconstructivism
Issue Date: 2006
Publisher: Elsevier
Citation: Li S, Brehmer Y, Shing YL, Werkle-Bergner M & Lindenberger U (2006) Neuromodulation of associative and organizational plasticity across the life span: Empirical evidence and neurocomputational modeling, Neuroscience and Biobehavioral Reviews, 30 (6), pp. 775-790.
Abstract: Developmental plasticity is the key mechanism that allows humans and other organisms to modify and adapt to contextual and experiential influences. Thus, reciprocal co-constructive interactions between behavioral and neuronal plasticity play important roles in regulating neurobehavioral development across the life span. This review focuses on behavioral and neuronal evidence of lifespan differences in associative memory plasticity and plasticity of the functional organization of cognitive and cortical processes, as well as the role of the dopaminergic system in modulating such plasticity. Special attention is given to neurocomputational models that help exploring lifespan differences in neuromodulation of neuronal and behavioral plasticity. Simulation results from these models suggest that lifespan changes in the efficacy of neuromodulatory mechanisms may shape associative memory plasticity and the functional organization of neurocognitive processes by affecting the fidelity of neuronal signal transmission, which has consequences for the distinctiveness of neurocognitive representations and the efficacy of distributed neural coding.
Type: Journal Article
URI: http://hdl.handle.net/1893/22266
DOI Link: http://dx.doi.org/10.1016/j.neubiorev.2006.06.004
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Max Planck Institute for Human Development
Max Planck Institute for Human Development
Psychology
Max Planck Institute for Human Development
Max Planck Institute for Human Development

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