|Appears in Collections:||Computing Science and Mathematics Journal Articles|
|Peer Review Status:||Refereed|
|Title:||A mathematical model on CTL mediated control of hiv infection in a long-term drug therapy|
|Authors:||Roy, Priti Kumar|
Chatterjee, Amar Nath
T Cell Proliferation
|Citation:||Roy PK, Chowdhury S, Chatterjee AN, Chattopadhyay J & Norman R (2013) A mathematical model on CTL mediated control of hiv infection in a long-term drug therapy, Journal of Biological Systems, 21 (3), Art. No.: 1350019.|
|Abstract:||Bonhoeffer et al.1 studied the long-term dynamics of HIV drug therapy and virus load dynamics. It is well known that highly active anti retroviral therapy (HAART) can effectively control the HIV replication. It is also well known that reverse transcriptase inhibitors (RTIs) could block new infection and as a result control HIV infection. The positive feedback control on such dynamics plays an important role and CD4+T cells are not only produced from a source but also produced from existing T cells. The present investigation takes into account these factors in the original model of Bonhoeffer et al. The optimal control therapy and the effect of time delay in the positive feedback control function have been investigated. Numerical simulation of the nonlinear model has confirmed our analytical studies.Read More: http://www.worldscientific.com/doi/abs/10.1142/S0218339013500198|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Roy et al_JBS_2013.pdf||796.97 kB||Adobe PDF||Under Embargo until 31/12/2999 Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact firstname.lastname@example.org providing details and we will remove the Work from public display in STORRE and investigate your claim.