Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22129
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Place field repetition and spatial learning in a multicompartment environment
Authors: Grieves, Roderick
Jenkins, Bryan W
Harland, Bruce
Wood, Emma R
Dudchenko, Paul
Contact Email: p.a.dudchenko@stir.ac.uk
Keywords: spatial cognition
place cell
hippocampus
odor discrimination
context discrimination
Issue Date: Jan-2016
Publisher: Wiley-Blackwell
Citation: Grieves R, Jenkins BW, Harland B, Wood ER & Dudchenko P (2016) Place field repetition and spatial learning in a multicompartment environment, Hippocampus, 26 (1), pp. 118-134.
Abstract: Recent studies have shown that place cells in the hippocampus possess firing fields that repeat in physically similar, parallel environments. These results imply that it should be difficult for animals to distinguish parallel environments at a behavioral level. To test this, we trained rats on a novel odor-location task in an environment with four parallel compartments which had previously been shown to yield place field repetition. A second group of animals was trained on the same task, but with the compartments arranged in different directions, an arrangement we hypothesised would yield less place field repetition. Learning of the odor-location task in the parallel compartments was significantly impaired relative to learning in the radially arranged compartments. Fewer animals acquired the full discrimination in the parallel compartments compared to those trained in the radial compartments, and the former also required many more sessions to reach criterion compared to the latter. To confirm that the arrangement of compartments yielded differences in place cell repetition, in a separate group of animals we recorded from CA1 place cells in both environments. We found that CA1 place cells exhibited repeated fields across four parallel local compartments, but did not do so when the same compartments were arranged radially. To confirm that the differences in place field repetition across the parallel and radial compartments depended on their angular arrangement, and not incidental differences in access to an extra-maze visual landmark, we repeated the recordings in a second set of rats in the absence of the orientation landmark. We found, once again, that place fields showed repetition in parallel compartments, and did not do so in radially arranged compartments. Thus place field repetition, or lack thereof, in these compartments was not dependent on extra-maze cues. Together, these results imply that place field repetition constrains spatial learning. © 2015 Wiley Periodicals, Inc.
Type: Journal Article
URI: http://hdl.handle.net/1893/22129
DOI Link: http://dx.doi.org/10.1002/hipo.22496
Rights: This article is open-access. Open access publishing allows free access to and distribution of published articles where the author retains copyright of their work by employing a Creative Commons attribution licence. Proper attribution of authorship and correct citation details should be given
Affiliation: Psychology
University of Edinburgh
Psychology
University of Edinburgh
Psychology

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