|Appears in Collections:||Psychology Journal Articles|
|Peer Review Status:||Refereed|
|Title:||On the functions, mechanisms, and malfunctions of intracortical contextual modulation|
Silverstein, Steven M
|Citation:||Phillips W, Clark A & Silverstein SM (2015) On the functions, mechanisms, and malfunctions of intracortical contextual modulation, Neuroscience and Biobehavioral Reviews, 52, pp. 1-20.|
|Abstract:||A broad neuron-centric conception of contextual modulation is reviewed and re-assessed in the light of recent neurobiological studies of amplification, suppression, and synchronization. Behavioural and computational studies of perceptual and higher cognitive functions that depend on these processes are outlined, and evidence that those functions and their neuronal mechanisms are impaired in schizophrenia is summarized. Finally, we compare and assess the long-term biological functions of contextual modulation at the level of computational theory as formalized by the theories of coherent infomax and free energy reduction. We conclude that those theories, together with the many empirical findings reviewed, show how contextual modulation at the neuronal level enables the cortex to flexibly adapt the use of its knowledge to current circumstances by amplifying and grouping relevant activities and by suppressing irrelevant activities.|
|Rights:||This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Phillips W, Clark A & Silverstein SM (2015) On the functions, mechanisms, and malfunctions of intracortical contextual modulation, Neuroscience and Biobehavioral Reviews, 52, pp. 1-20. DOI: 10.1016/j.neubiorev.2015.02.010 © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/|
|PCS 2015 Pre-publication version.pdf||789.05 kB||Adobe PDF||View/Open|
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