Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21409
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Analysis of the rainbow trout solute carrier 11 family reveals iron import ≤ pH 7.4 and a functional isoform lacking transmembrane domains 11 and 12
Authors: Cooper, Christopher A
Shayeghi, Majid
Techau, Michala E
Capdevila, Davinia Morera
MacKenzie, Simon
Durrant, Christopher J
Bury, Nicholas R
Contact Email: simon.mackenzie@stir.ac.uk
Keywords: Divalent metal transporter 1 (DMT1)
Iron
Natural resistance-associated macrophage protein (Nramp)
Fish
Transmembrane domains
Rainbow trout
Issue Date: 12-Jun-2007
Publisher: Elsevier
Citation: Cooper CA, Shayeghi M, Techau ME, Capdevila DM, MacKenzie S, Durrant CJ & Bury NR (2007) Analysis of the rainbow trout solute carrier 11 family reveals iron import ≤ pH 7.4 and a functional isoform lacking transmembrane domains 11 and 12, FEBS Letters, 581 (14), pp. 2599-2604.
Abstract: A Xenopus oocyte heterologous expression system was used to characterise iron transport properties of two members of the solute carrier 11 (slc11) protein family isolated from rainbow trout gills. One cDNA clone differed from the trout Slc11α containing an additional 52bp in the exon between transmembrane domains (TM) 10 and 11. The 52bp contained a stop codon, resulting in a novel isoform lacking the last two TM (termed slc11γ). Slc11γ and another isoform slc11β, import Fe2+ at external pHs ⩽ to 7.4. Trout slc11β Fe2+ import was more sensitive to inhibition by divalent metals. The novel vertebrate slc11γ isoform functions without TM11 and 12.
Type: Journal Article
URI: http://hdl.handle.net/1893/21409
DOI Link: http://dx.doi.org/10.1016/j.febslet.2007.04.081
Rights: Made available under an Elsevier Open Archive user license: Articles published under an Elsevier user license are protected by copyright and may be used for non-commercial purposes. Users may access, download, copy, display, redistribute, adapt, translate, text mine and data mine the articles provided that users: •Cite the article using an appropriate bibliographic citation (i.e. author(s), journal, article title, volume, issue, page numbers, DOI and the link to the definitive published version on ScienceDirect) •Use the article for non- commercial purposes •Maintain the integrity of the article •Retain copyright notices and links to these terms and conditions so it is clear to other users what can and cannot be done with the article •Ensure that, for any content in the article that is identified as belonging to a third party, any re-use complies with the copyright policies of that third party This is a non commercial license where the use of published articles for commercial purposes is prohibited.
Affiliation: King's College London
King's College London
University of Cambridge
Universitat Autonoma de Barcelona
Complex Systems
King's College London
King's College London

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