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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21409
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dc.contributor.authorCooper, Christopher Aen_UK
dc.contributor.authorShayeghi, Majiden_UK
dc.contributor.authorTechau, Michala Een_UK
dc.contributor.authorCapdevila, Davinia Moreraen_UK
dc.contributor.authorMacKenzie, Simonen_UK
dc.contributor.authorDurrant, Christopher Jen_UK
dc.contributor.authorBury, Nicholas Ren_UK
dc.date.accessioned2015-01-28T23:18:42Z-
dc.date.available2015-01-28T23:18:42Z-
dc.date.issued2007-06-12en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21409-
dc.description.abstractA Xenopus oocyte heterologous expression system was used to characterise iron transport properties of two members of the solute carrier 11 (slc11) protein family isolated from rainbow trout gills. One cDNA clone differed from the trout Slc11α containing an additional 52bp in the exon between transmembrane domains (TM) 10 and 11. The 52bp contained a stop codon, resulting in a novel isoform lacking the last two TM (termed slc11γ). Slc11γ and another isoform slc11β, import Fe2+ at external pHs ⩽ to 7.4. Trout slc11β Fe2+ import was more sensitive to inhibition by divalent metals. The novel vertebrate slc11γ isoform functions without TM11 and 12.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationCooper CA, Shayeghi M, Techau ME, Capdevila DM, MacKenzie S, Durrant CJ & Bury NR (2007) Analysis of the rainbow trout solute carrier 11 family reveals iron import ≤ pH 7.4 and a functional isoform lacking transmembrane domains 11 and 12. FEBS Letters, 581 (14), pp. 2599-2604. https://doi.org/10.1016/j.febslet.2007.04.081en_UK
dc.rightsMade available under an Elsevier Open Archive user license: Articles published under an Elsevier user license are protected by copyright and may be used for non-commercial purposes. Users may access, download, copy, display, redistribute, adapt, translate, text mine and data mine the articles provided that users: •Cite the article using an appropriate bibliographic citation (i.e. author(s), journal, article title, volume, issue, page numbers, DOI and the link to the definitive published version on ScienceDirect) •Use the article for non- commercial purposes •Maintain the integrity of the article •Retain copyright notices and links to these terms and conditions so it is clear to other users what can and cannot be done with the article •Ensure that, for any content in the article that is identified as belonging to a third party, any re-use complies with the copyright policies of that third party This is a non commercial license where the use of published articles for commercial purposes is prohibited.en_UK
dc.subjectDivalent metal transporter 1 (DMT1)en_UK
dc.subjectIronen_UK
dc.subjectNatural resistance-associated macrophage protein (Nramp)en_UK
dc.subjectFishen_UK
dc.subjectTransmembrane domainsen_UK
dc.subjectRainbow trouten_UK
dc.titleAnalysis of the rainbow trout solute carrier 11 family reveals iron import ≤ pH 7.4 and a functional isoform lacking transmembrane domains 11 and 12en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.febslet.2007.04.081en_UK
dc.citation.jtitleFEBS Lettersen_UK
dc.citation.issn1873-3468en_UK
dc.citation.issn0014-5793en_UK
dc.citation.volume581en_UK
dc.citation.issue14en_UK
dc.citation.spage2599en_UK
dc.citation.epage2604en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailsimon.mackenzie@stir.ac.uken_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationUniversity of Cambridgeen_UK
dc.contributor.affiliationUniversitat Autonoma de Barcelonaen_UK
dc.contributor.affiliationComplex Systems - LEGACYen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.identifier.isiWOS:000247324300005en_UK
dc.identifier.scopusid2-s2.0-34249665580en_UK
dc.identifier.wtid605807en_UK
dc.contributor.orcid0000-0003-1845-6826en_UK
dcterms.dateAccepted2007-06-12en_UK
dc.date.filedepositdate2015-01-28en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorCooper, Christopher A|en_UK
local.rioxx.authorShayeghi, Majid|en_UK
local.rioxx.authorTechau, Michala E|en_UK
local.rioxx.authorCapdevila, Davinia Morera|en_UK
local.rioxx.authorMacKenzie, Simon|0000-0003-1845-6826en_UK
local.rioxx.authorDurrant, Christopher J|en_UK
local.rioxx.authorBury, Nicholas R|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2015-01-28en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2015-01-28|en_UK
local.rioxx.filenameMacKenzie_FEBS Letters 2007.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0014-5793en_UK
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