Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21307
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: The role of endogenous opioids in non-suicidal self-injurious behavior: Methodological challenges
Authors: Kirtley, Olivia J
O'Carroll, Ronan
O'Connor, Rory C
Contact Email: ronan.ocarroll@stir.ac.uk
Keywords: NSSI
Self-harm
Self-injury
Opioids
Ideation
Cannabinoids
Methodology
Issue Date: Jan-2015
Publisher: Elsevier
Citation: Kirtley OJ, O'Carroll R & O'Connor RC (2015) The role of endogenous opioids in non-suicidal self-injurious behavior: Methodological challenges, Neuroscience and Biobehavioral Reviews, 48, pp. 186-189.
Abstract: Relief from emotional pain is a frequently cited reason for engaging in non-suicidal self-injury. The exact mechanism by which self-injury brings about this relief is unknown, but the potential role of endogenous opioids in affective regulation has been posited. Few studies have investigated this and there are a number of methodological challenges to measuring endogenous opioid activity in this population. Furthermore as the majority of research to date has focused on inpatients with borderline personality disorder (BPD), it is uncertain if the findings of previous studies would also apply to those who self-injure but who do not have BPD. Whether or not altered endogenous opioid levels are a cause or a consequence of self-injury is unknown and to this end, comparing self-injury ideators with enactors, may offer a window of insight. Another candidate system, the endocannabinoid system, should also be explored in relation to this research question. The current commentary aims to tease apart the methodological issues in this area of research and stimulate further discussion of this topic.
Type: Journal Article
URI: http://hdl.handle.net/1893/21307
DOI Link: http://dx.doi.org/10.1016/j.neubiorev.2014.11.007
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Glasgow
Psychology
University of Glasgow

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