Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21288
Appears in Collections:Computing Science and Mathematics Journal Articles
Peer Review Status: Refereed
Title: On phasic inhibition during hippocampal theta
Authors: Graham, Bruce
Spera, Emiliano
Contact Email: b.p.graham@stir.ac.uk
Keywords: Oscillations
single neuron computation
synaptic plasticity
Issue Date: Mar-2014
Publisher: Informa Healthcare
Citation: Graham B & Spera E (2014) On phasic inhibition during hippocampal theta, Network: Computation in Neural Systems, 25 (1-2), pp. 3-19.
Abstract: Two computational models are used to explore the possible implications of recent experimental data (Royer et al. 2012) on phasic inhibition during theta frequency (4-10 Hz) oscillations in the hippocampi of actively behaving rodents. A working hypothesis from previous experimental and modelling studies is that a theta cycle is divided into encoding (when synaptic plasticity is enhanced) and recall (when plasticity is suppressed) half cycles. Using a compartmental model of a CA1 pyramidal cell, including dendritic spines, we demonstrate that out-of-phase perisomatic and dendritic inhibition, respectively, can promote the necessary conditions for these half cycles. Perisomatic inhibition allows dendritic calcium spikes that promote synaptic LTP, while minimising cell output. Dendritic inhibition, on the other hand, both controls cell output and suppresses dendritic calcium spikes, preventing LTP. The exact phase relationship between these sub-cycles may not be fixed. Using a simple sum-of-sinusoids activity model, we suggest an interpretation of the data of Royer et al. (2012) in which a fixed-phase encoding sub-cycle is surrounded by a flexible-phase recall cycle that follows the peak of excitatory drive and consequent phase precession of activity as an animal passes through a pyramidal cell's place field.
Type: Journal Article
URI: http://hdl.handle.net/1893/21288
URL: http://www.tandfonline.com/doi/full/10.3109/0954898X.2014.886346
DOI Link: http://dx.doi.org/10.3109/0954898X.2014.886346
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Computing Science - CSM Dept
University of Stirling

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