Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21208
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: A Canadian case-control study
Authors: Brophy, James T
Keith, Margaret M
Watterson, Andrew
Park, Robert M
Gilbertson, Michael
Maticka-Tyndale, Eleanor
Beck, Matthias
Abu-Zahra, Hakam
Schneider, Kenneth
Reinhartz, Abraham
DeMatteo, Robert
Luginaah, Isaac N
Keywords: Agriculture
Breast cancer
Canning
Casino
Carcinogen
Endocrine disruptor
Metals
Occupational
Plastics
Issue Date: Nov-2012
Publisher: BioMed Central
Citation: Brophy JT, Keith MM, Watterson A, Park RM, Gilbertson M, Maticka-Tyndale E, Beck M, Abu-Zahra H, Schneider K, Reinhartz A, DeMatteo R & Luginaah IN (2012) Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: A Canadian case-control study, Environmental Health, 11 (1), Art. No.: 87.
Abstract: Background: Endocrine disrupting chemicals and carcinogens, some of which may not yet have been classified as such, are present in many occupational environments and could increase breast cancer risk. Prior research has identified associations with breast cancer and work in agricultural and industrial settings. The purpose of this study was to further characterize possible links between breast cancer risk and occupation, particularly in farming and manufacturing, as well as to examine the impacts of early agricultural exposures, and exposure effects that are specific to the endocrine receptor status of tumours. Methods: 1005 breast cancer cases referred by a regional cancer center and 1146 randomly-selected community controls provided detailed data including occupational and reproductive histories. All reported jobs were industry- and occupation-coded for the construction of cumulative exposure metrics representing likely exposure to carcinogens and endocrine disruptors. In a frequency-matched case-control design, exposure effects were estimated using conditional logistic regression. Results: Across all sectors, women in jobs with potentially high exposures to carcinogens and endocrine disruptors had elevated breast cancer risk (OR = 1.42; 95% CI, 1.18-1.73, for 10 years exposure duration). Specific sectors with elevated risk included: agriculture (OR = 1.36; 95% CI, 1.01-1.82); bars-gambling (OR = 2.28; 95% CI, 0.94-5.53); automotive plastics manufacturing (OR = 2.68; 95% CI, 1.47-4.88), food canning (OR = 2.35; 95% CI, 1.00-5.53), and metalworking (OR = 1.73; 95% CI, 1.02-2.92). Estrogen receptor status of tumors with elevated risk differed by occupational grouping. Premenopausal breast cancer risk was highest for automotive plastics (OR = 4.76; 95% CI, 1.58-14.4) and food canning (OR = 5.70; 95% CI, 1.03-31.5). Conclusions: These observations support hypotheses linking breast cancer risk and exposures likely to include carcinogens and endocrine disruptors, and demonstrate the value of detailed work histories in environmental and occupational epidemiology.
Type: Journal Article
URI: http://hdl.handle.net/1893/21208
DOI Link: http://dx.doi.org/10.1186/1476-069X-11-87
Rights: © 2012 Brophy et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Affiliation: University of Windsor
University of Windsor
HS Research - Stirling
National Institute for Occupational Safety and Health
University of Stirling
University of Windsor
Queen's University Belfast
Windsor Regional Cancer Centre
Windsor Regional Cancer Centre
Occupational Health Clinics for Ontario Workers
Occupational Health Clinics for Ontario Workers
University of Windsor

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