Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21208
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dc.contributor.authorBrophy, James Ten_UK
dc.contributor.authorKeith, Margaret Men_UK
dc.contributor.authorWatterson, Andrewen_UK
dc.contributor.authorPark, Robert Men_UK
dc.contributor.authorGilbertson, Michaelen_UK
dc.contributor.authorMaticka-Tyndale, Eleanoren_UK
dc.contributor.authorBeck, Matthiasen_UK
dc.contributor.authorAbu-Zahra, Hakamen_UK
dc.contributor.authorSchneider, Kennethen_UK
dc.contributor.authorReinhartz, Abrahamen_UK
dc.contributor.authorDeMatteo, Roberten_UK
dc.contributor.authorLuginaah, Isaac Nen_UK
dc.date.accessioned2018-04-26T02:42:44Z-
dc.date.available2018-04-26T02:42:44Z-
dc.date.issued2012-11en_UK
dc.identifier.other87en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21208-
dc.description.abstractBackground: Endocrine disrupting chemicals and carcinogens, some of which may not yet have been classified as such, are present in many occupational environments and could increase breast cancer risk. Prior research has identified associations with breast cancer and work in agricultural and industrial settings. The purpose of this study was to further characterize possible links between breast cancer risk and occupation, particularly in farming and manufacturing, as well as to examine the impacts of early agricultural exposures, and exposure effects that are specific to the endocrine receptor status of tumours. Methods: 1005 breast cancer cases referred by a regional cancer center and 1146 randomly-selected community controls provided detailed data including occupational and reproductive histories. All reported jobs were industry- and occupation-coded for the construction of cumulative exposure metrics representing likely exposure to carcinogens and endocrine disruptors. In a frequency-matched case-control design, exposure effects were estimated using conditional logistic regression. Results: Across all sectors, women in jobs with potentially high exposures to carcinogens and endocrine disruptors had elevated breast cancer risk (OR = 1.42; 95% CI, 1.18-1.73, for 10 years exposure duration). Specific sectors with elevated risk included: agriculture (OR = 1.36; 95% CI, 1.01-1.82); bars-gambling (OR = 2.28; 95% CI, 0.94-5.53); automotive plastics manufacturing (OR = 2.68; 95% CI, 1.47-4.88), food canning (OR = 2.35; 95% CI, 1.00-5.53), and metalworking (OR = 1.73; 95% CI, 1.02-2.92). Estrogen receptor status of tumors with elevated risk differed by occupational grouping. Premenopausal breast cancer risk was highest for automotive plastics (OR = 4.76; 95% CI, 1.58-14.4) and food canning (OR = 5.70; 95% CI, 1.03-31.5). Conclusions: These observations support hypotheses linking breast cancer risk and exposures likely to include carcinogens and endocrine disruptors, and demonstrate the value of detailed work histories in environmental and occupational epidemiology.en_UK
dc.language.isoenen_UK
dc.publisherBioMed Centralen_UK
dc.relationBrophy JT, Keith MM, Watterson A, Park RM, Gilbertson M, Maticka-Tyndale E, Beck M, Abu-Zahra H, Schneider K, Reinhartz A, DeMatteo R & Luginaah IN (2012) Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: A Canadian case-control study. Environmental Health, 11 (1), Art. No.: 87. https://doi.org/10.1186/1476-069X-11-87en_UK
dc.rights© 2012 Brophy et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en_UK
dc.subjectAgricultureen_UK
dc.subjectBreast canceren_UK
dc.subjectCanningen_UK
dc.subjectCasinoen_UK
dc.subjectCarcinogenen_UK
dc.subjectEndocrine disruptoren_UK
dc.subjectMetalsen_UK
dc.subjectOccupationalen_UK
dc.subjectPlasticsen_UK
dc.titleBreast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: A Canadian case-control studyen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1186/1476-069X-11-87en_UK
dc.identifier.pmid23164221en_UK
dc.citation.jtitleEnvironmental Healthen_UK
dc.citation.issn1476-069Xen_UK
dc.citation.volume11en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Windsoren_UK
dc.contributor.affiliationUniversity of Windsoren_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationNational Institute for Occupational Safety and Healthen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Windsoren_UK
dc.contributor.affiliationQueen's University Belfasten_UK
dc.contributor.affiliationWindsor Regional Cancer Centreen_UK
dc.contributor.affiliationWindsor Regional Cancer Centreen_UK
dc.contributor.affiliationOccupational Health Clinics for Ontario Workersen_UK
dc.contributor.affiliationOccupational Health Clinics for Ontario Workersen_UK
dc.contributor.affiliationUniversity of Windsoren_UK
dc.identifier.isiWOS:000313338800001en_UK
dc.identifier.scopusid2-s2.0-84871788061en_UK
dc.identifier.wtid886064en_UK
dcterms.dateAccepted2012-11-30en_UK
dc.date.filedepositdate2014-11-05en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorBrophy, James T|en_UK
local.rioxx.authorKeith, Margaret M|en_UK
local.rioxx.authorWatterson, Andrew|en_UK
local.rioxx.authorPark, Robert M|en_UK
local.rioxx.authorGilbertson, Michael|en_UK
local.rioxx.authorMaticka-Tyndale, Eleanor|en_UK
local.rioxx.authorBeck, Matthias|en_UK
local.rioxx.authorAbu-Zahra, Hakam|en_UK
local.rioxx.authorSchneider, Kenneth|en_UK
local.rioxx.authorReinhartz, Abraham|en_UK
local.rioxx.authorDeMatteo, Robert|en_UK
local.rioxx.authorLuginaah, Isaac N|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2014-11-05en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/2.0/|2014-11-05|en_UK
local.rioxx.filenameEnvironmental Health 2012.pdfen_UK
local.rioxx.filecount1en_UK
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