Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21096
Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Signalling mechanisms of the leukocyte integrin αMβ2: Current and future perspectives
Authors: Lim, Jenson
Hotchin, Neil A
Contact Email: jenson.lim@stir.ac.uk
Keywords: alphaMβ2
Integrin
Macrophages
Phagocytosis
Talin
Issue Date: Nov-2012
Publisher: Wiley-Blackwell
Citation: Lim J & Hotchin NA (2012) Signalling mechanisms of the leukocyte integrin αMβ2: Current and future perspectives, Biology of the Cell, 104 (11), pp. 631-640.
Abstract: Integrins are a family of heterodimeric cell adhesion receptors expressed on most cells and are involved in many cellular functions including phagocytosis, a process by which professional phagocytes recognise, bind and internalise foreign materials larger than 0.5 µm in diameter. An example of a phagocytic integrin receptor is Mβ2, and this review seeks to provide fresh insights into the current knowledge of this subject. Key areas that this review will emphasise include, the classical understanding of bi-directional signalling to and from Mβ2 (aka inside-out and outside-in signalling, respectively). For inside-out signalling, we will review the involvement of the small GTPase, Rap1, FERM-containing proteins such as talin and kindlin-3, some of the kinases, and the GEF, cytohesin-1 and vasodilator-stimulated phosphoprotein (VASP). We also summarise studies into outside-in signalling, focussing on the roles of RhoA and RhoG, and activation of Rac1 through the complex comprising TIAM, 14-3-3 and β2. We will also consider non-classical signalling processes, which include integrin clustering and membrane ruffling. Through this review, we hope to highlight the importance of Mβ2 signalling mechanisms and their relevance to other integrin-mediated events.
Type: Journal Article
URI: http://hdl.handle.net/1893/21096
DOI Link: http://dx.doi.org/10.1111/boc.201200013
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Biological and Environmental Sciences
University of Birmingham

Files in This Item:
File Description SizeFormat 
2012 Lim and Hotchin final.pdf305.79 kBAdobe PDFUnder Embargo until 31/12/2999     Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.

This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.