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Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Phagocytosis, an alternative model system for the study of cell adhesion
Authors: Cougoule, Celine
Wiedemann, Agnes
Lim, Jenson
Caron, Emmanuelle
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Keywords: Phagocytic uptake
Small GTP-binding proteins
Actin cytoskeleton
Issue Date: Dec-2004
Publisher: Elsevier
Citation: Cougoule C, Wiedemann A, Lim J & Caron E (2004) Phagocytosis, an alternative model system for the study of cell adhesion, Seminars in Cell and Developmental Biology, 15 (6), pp. 679-689.
Abstract: Cell adhesion encompasses a variety of cell-cell and cell-matrix adhesive interactions. Whereas ligation of most adhesion receptors activate Rho-family GTP-binding proteins and the subsequent reorganization of the actin cytoskeleton, the molecular mechanisms involved remain poorly understood. Because phagocytosis is a spatially restricted adhesion process, it represents a simplified model system to investigate the spatio-temporal regulation of the signalling pathways that link surface adhesion receptors, small GTPases and the actin cytoskeleton. This review highlights some of the similarities between the formation and maintenance of adhesive contacts and phagocytic uptake and discusses why the study of phagocytosis can help understand more complex adhesion processes.
Type: Journal Article
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Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Imperial College London
Imperial College London
Biological and Environmental Sciences
Imperial College London

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