Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21031
Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Wild Mandrillus sphinx are carriers of two types of lentivirus
Authors: Souquiere, Sandrine
Bibollet-Ruche, Frederic
Robertson, David L
Makuwa, Maria
Apetrei, Cristian
Onanga, Richard
Kornfeld, Christopher
Plantier, Jean-Christophe
Gao, Feng
Abernethy, Katharine
White, Lee
Karesh, William B
Telfer, Paul T
Wickings, E Jean
Mauclere, Philippe
Contact Email: k.a.abernethy@stir.ac.uk
Issue Date: Aug-2001
Publisher: American Society for Microbiology
Citation: Souquiere S, Bibollet-Ruche F, Robertson DL, Makuwa M, Apetrei C, Onanga R, Kornfeld C, Plantier J, Gao F, Abernethy K, White L, Karesh WB, Telfer PT, Wickings EJ & Mauclere P (2001) Wild Mandrillus sphinx are carriers of two types of lentivirus, Journal of Virology, 75 (15), pp. 7086-7096.
Abstract: Mandrillus sphinx, a large primate living in Cameroon and Gabon and belonging to the Papionini tribe, was reported to be infected by a simian immunodeficiency virus (SIV) (SIVmndGB1) as early as 1988. Here, we have identified a second, highly divergent SIVmnd (designated SIVmnd-2). Genomic organization differs between the two viral types; SIVmnd-2 has the additionalvpx gene, like other SIVs naturally infecting the Papionini tribe (SIVsm and SIVrcm) and in contrast to the other SIVmnd type (here designated SIVmnd-1), which is more closely related to SIVs infecting l'hoest (Cercopithecus lhoesti lhoesti) and sun-tailed (Cercopithecus lhoesti solatus) monkeys. Importantly, our epidemiological studies indicate a high prevalence of both types of SIVmnd; all 10 sexually mature wild-living monkeys and 3 out of 17 wild-born juveniles tested were infected. The geographic distribution of SIVmnd seems to be distinct for the two types: SIVmnd-1 viruses were exclusively identified in mandrills from central and southern Gabon, whereas SIVmnd-2 viruses were identified in monkeys from northern and western Gabon, as well as in Cameroon. SIVmnd-2 full-length sequence analysis, together with analysis of partial sequences from SIVmnd-1 and SIVmnd-2 from wild-born or wild-living mandrills, shows that thegag and pol regions of SIVmnd-2 are closest to those of SIVrcm, isolated from red-capped mangabeys (Cercocebus torquatus), while the env gene is closest to that of SIVmnd-1. pol and env sequence analyses of SIV from a related Papionini species, the drill (Mandrillus leucophaeus), shows a closer relationship of SIVdrl to SIVmnd-2 than to SIVmnd-1. Epidemiological surveys of human immunodeficiency virus revealed a case in Cameroon of a human infected by a virus serologically related to SIVmnd, raising the possibility that mandrills represent a viral reservoir for humans similar to sooty mangabeys in Western Africa and chimpanzees in Central Africa.
Type: Journal Article
URI: http://hdl.handle.net/1893/21031
DOI Link: http://dx.doi.org/10.1128/JVI.75.15.7086-7096.2001
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Notes: Additional co-authors: Preston A. Marx, Françoise Barré-Sinoussi, Beatrice H. Hahn, Michaela C. Müller-Trutwin, and François Simon
Affiliation: Centre International de Recherches Médicales de Franceville
University of Alabama at Birmingham
University of Oxford
Centre International de Recherches Médicales de Franceville
Centre International de Recherches Médicales de Franceville
Centre International de Recherches Médicales de Franceville
Institut Pasteur
Rouen University Hospital – Charles Nicolle (CHU de Rouen)
University of Alabama at Birmingham
Biological and Environmental Sciences
Biological and Environmental Sciences
Wildlife Conservation Society (North America Program)
Centre International de Recherches Médicales de Franceville
Centre International de Recherches Médicales de Franceville
Pasteur Centre in Cameroon (CPC)

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