Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21030
Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: High levels of SIVmnd-1 replication in chronically infected Mandrillus sphinx
Authors: Pandrea, Ivona
Onanga, Richard
Kornfeld, Christopher
Rouquet, Pierre
Bourry, Olivier
Clifford, Stephen L
Telfer, Paul T
Abernethy, Katharine
White, Lee
Ngari, Paul
Muller-Trutwin, Michaela
Roques, Pierre
Marx, Preston A
Simon, Francois
Apetrei, Cristian
Contact Email: k.a.abernethy@stir.ac.uk
Keywords: SIVmnd-1
pathogenesis
mandrills
viral load
lymphocyte subsets
Issue Date: 5-Dec-2003
Publisher: Elsevier
Citation: Pandrea I, Onanga R, Kornfeld C, Rouquet P, Bourry O, Clifford SL, Telfer PT, Abernethy K, White L, Ngari P, Muller-Trutwin M, Roques P, Marx PA, Simon F & Apetrei C (2003) High levels of SIVmnd-1 replication in chronically infected Mandrillus sphinx, Virology, 317 (1), pp. 119-127.
Abstract: Viral loads were investigated in SIVmnd-1 chronically infected mandrills and the results were compared with those previously observed in other nonpathogenic natural SIV infections. Four naturally and 11 experimentally SIVmnd-1-infected mandrills from a semi-free-ranging colony were studied during the chronic phase of infection. Four SIVmnd-1-infected wild mandrills were also included for comparison. Twelve uninfected mandrills were used as controls. Viral loads in all chronically infected mandrills ranged from 105 to 9 × 105 copies/ml and antibody titers ranged from 200 to 14,400 and 200 to 12,800 for anti-V3 and anti-gp36, respectively. There were no differences between groups of wild and captive mandrills. Both parameters were stable during the follow-up, and no clinical signs of immune suppression were observed. Chronic SIVmnd-1-infected mandrills presented slight increases in CD20+ and CD28+ /CD8+ cell counts, and a slight decrease in CD4+ /CD3+ cell counts. A slight CD4+ /CD3+ cell depletion was also observed in old uninfected controls. Similar to other nonpathogenic models of lentiviral infection, these results show a persistent high level of SIVmnd-1 replication during chronic infection of mandrills, with minimal effects on T cell subpopulations.
Type: Journal Article
URI: http://hdl.handle.net/1893/21030
DOI Link: http://dx.doi.org/10.1016/j.virol.2003.08.015
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Centre International de Recherches Médicales de Franceville
Centre International de Recherches Médicales de Franceville
Institut Pasteur
Centre International de Recherches Médicales de Franceville
Centre International de Recherches Médicales de Franceville
Centre International de Recherches Médicales de Franceville
Centre International de Recherches Médicales de Franceville
Biological and Environmental Sciences
Biological and Environmental Sciences
Centre International de Recherches Médicales de Franceville
Institut Pasteur
Centre International de Recherches Médicales de Franceville
Tulane University
Institut Pasteur de Dakar
Centre International de Recherches Médicales de Franceville

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