Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21018
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: Insights from the STAND programme of research
Authors: Wilmot, Emma G
Edwardson, Charlotte L
Biddle, Stuart J H
Gorely, Trish
Henson, Joseph
Khunti, Kamlesh
Nimmo, Myra A
Yates, Thomas
Davies, Melanie J
Contact Email: trish.gorely@stir.ac.uk
Issue Date: Jun-2013
Publisher: Wiley-Blackwell
Citation: Wilmot EG, Edwardson CL, Biddle SJH, Gorely T, Henson J, Khunti K, Nimmo MA, Yates T & Davies MJ (2013) Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: Insights from the STAND programme of research, Diabetic Medicine, 30 (6), pp. 671-675.
Abstract: Aims: Rising rates of obesity have led to an increasing prevalence of Type 2 diabetes mellitus in young people. Uncertainty exists over the utility of screening younger adults for Type 2 diabetes, as existing data sets have focused on mature (> 40 years) cohorts. The aim of this study was to determine the prevalence of impaired glucose metabolism in higher risk younger adults. Methods: Overweight (with an additional risk factor) or obese adults (18-40 years) were recruited for the Sedentary Time And Diabetes (STAND) randomized controlled trial. Measures included an oral glucose tolerance test, HbA1c, biochemical and anthropometric data. Results: One hundred and ninety-three individuals (68% female; median age 33.8 years; median BMI 33.9 kg/m2) were recruited. Forty-three per cent had a first-degree family history of Type 2 diabetes. Previously undiagnosed Type 2 diabetes was present in 4.7% (n = 9). Of participants, 18.1% (n = 35) had impaired glucose metabolism: 4.7% (n = 9) HbA1c ≥ 48 mmol/mol (6.5%); 9.3% (n = 18) HbA1c 42-46 mmol/mol (6.0-6.4%); 3.1% (n = 6) Type 2 diabetes on oral glucose tolerance test; 6.2% (n = 12) isolated impaired glucose tolerance; 2.1% (n = 4) isolated impaired fasting glucose; 1% (n = 2) both impaired fasting glucose and impaired glucose tolerance. Of participants, 58.5% (n = 113) had dyslipidaemia, 28.0% (n = 54) had hypertension, 31.1% (n = 60) were vitamin D deficient and 7.3% (n = 14) had abnormal liver function. Conclusions: This study identified a high prevalence of Type 2 diabetes and impaired glucose regulation in overweight and obese younger adults. These findings require confirmation in a larger, representative, population.
Type: Journal Article
URI: http://hdl.handle.net/1893/21018
DOI Link: http://dx.doi.org/10.1111/dme.12173
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Leicester
University of Leicester
Loughborough University
Sport
University of Leicester
University of Leicester
Loughborough University
University of Leicester
University of Leicester

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