Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21018
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dc.contributor.authorWilmot, Emma Gen_UK
dc.contributor.authorEdwardson, Charlotte Len_UK
dc.contributor.authorBiddle, Stuart J Hen_UK
dc.contributor.authorGorely, Trishen_UK
dc.contributor.authorHenson, Josephen_UK
dc.contributor.authorKhunti, Kamleshen_UK
dc.contributor.authorNimmo, Myra Aen_UK
dc.contributor.authorYates, Thomasen_UK
dc.contributor.authorDavies, Melanie Jen_UK
dc.date.accessioned2016-08-26T00:13:25Z-
dc.date.available2016-08-26T00:13:25Z-
dc.date.issued2013-06en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21018-
dc.description.abstractAims: Rising rates of obesity have led to an increasing prevalence of Type 2 diabetes mellitus in young people. Uncertainty exists over the utility of screening younger adults for Type 2 diabetes, as existing data sets have focused on mature (> 40 years) cohorts. The aim of this study was to determine the prevalence of impaired glucose metabolism in higher risk younger adults. Methods: Overweight (with an additional risk factor) or obese adults (18-40 years) were recruited for the Sedentary Time And Diabetes (STAND) randomized controlled trial. Measures included an oral glucose tolerance test, HbA1c, biochemical and anthropometric data. Results: One hundred and ninety-three individuals (68% female; median age 33.8 years; median BMI 33.9 kg/m2) were recruited. Forty-three per cent had a first-degree family history of Type 2 diabetes. Previously undiagnosed Type 2 diabetes was present in 4.7% (n = 9). Of participants, 18.1% (n = 35) had impaired glucose metabolism: 4.7% (n = 9) HbA1c ≥ 48 mmol/mol (6.5%); 9.3% (n = 18) HbA1c 42-46 mmol/mol (6.0-6.4%); 3.1% (n = 6) Type 2 diabetes on oral glucose tolerance test; 6.2% (n = 12) isolated impaired glucose tolerance; 2.1% (n = 4) isolated impaired fasting glucose; 1% (n = 2) both impaired fasting glucose and impaired glucose tolerance. Of participants, 58.5% (n = 113) had dyslipidaemia, 28.0% (n = 54) had hypertension, 31.1% (n = 60) were vitamin D deficient and 7.3% (n = 14) had abnormal liver function. Conclusions: This study identified a high prevalence of Type 2 diabetes and impaired glucose regulation in overweight and obese younger adults. These findings require confirmation in a larger, representative, population.en_UK
dc.language.isoenen_UK
dc.publisherWiley-Blackwellen_UK
dc.relationWilmot EG, Edwardson CL, Biddle SJH, Gorely T, Henson J, Khunti K, Nimmo MA, Yates T & Davies MJ (2013) Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: Insights from the STAND programme of research. Diabetic Medicine, 30 (6), pp. 671-675. https://doi.org/10.1111/dme.12173en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titlePrevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: Insights from the STAND programme of researchen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[wilmot 2014 diabetes med STAND insights.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1111/dme.12173en_UK
dc.citation.jtitleDiabetic Medicineen_UK
dc.citation.issn1464-5491en_UK
dc.citation.issn0742-3071en_UK
dc.citation.volume30en_UK
dc.citation.issue6en_UK
dc.citation.spage671en_UK
dc.citation.epage675en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailtrish.gorely@uhi.ac.uken_UK
dc.contributor.affiliationUniversity of Leicesteren_UK
dc.contributor.affiliationUniversity of Leicesteren_UK
dc.contributor.affiliationLoughborough Universityen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Leicesteren_UK
dc.contributor.affiliationUniversity of Leicesteren_UK
dc.contributor.affiliationLoughborough Universityen_UK
dc.contributor.affiliationUniversity of Leicesteren_UK
dc.contributor.affiliationUniversity of Leicesteren_UK
dc.identifier.isiWOS:000319213600009en_UK
dc.identifier.scopusid2-s2.0-84878062314en_UK
dc.identifier.wtid620792en_UK
dc.date.accepted2013-03-13en_UK
dcterms.dateAccepted2013-03-13en_UK
dc.date.filedepositdate2014-08-26en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorWilmot, Emma G|en_UK
local.rioxx.authorEdwardson, Charlotte L|en_UK
local.rioxx.authorBiddle, Stuart J H|en_UK
local.rioxx.authorGorely, Trish|en_UK
local.rioxx.authorHenson, Joseph|en_UK
local.rioxx.authorKhunti, Kamlesh|en_UK
local.rioxx.authorNimmo, Myra A|en_UK
local.rioxx.authorYates, Thomas|en_UK
local.rioxx.authorDavies, Melanie J|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenamewilmot 2014 diabetes med STAND insights.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0742-3071en_UK
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