Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20650
Appears in Collections:Computing Science and Mathematics Journal Articles
Peer Review Status: Refereed
Title: A tool for synthesizing spike trains with realistic interference
Authors: Smith, Leslie
Mtetwa, Nhamoinesu
Contact Email: l.s.smith@stir.ac.uk
Keywords: Spike detection
Spike sorting
Synthetic data
Issue Date: Jan-2007
Publisher: Elsevier
Citation: Smith L & Mtetwa N (2007) A tool for synthesizing spike trains with realistic interference, Journal of Neuroscience Methods, 159 (1), pp. 170-180.
Abstract: Spike detection and spike sorting techniques are often difficult to assess because of the lack of ground truth data (i.e., spike timings for each neuron). This is particularly important for in vitro recordings where the signal to noise ratio is poor (as is the case for multi-electrode arrays at the bottom of a cell culture dish). We present an analysis of the transmission of intracellular signals from neurons to an extracellular electrode, and a set of MATLAB functions based on this analysis. These produce realistic signals from neighboring neurons as well as interference from more distant neurons, and Gaussian noise. They thus generate realistic but controllable synthetic signals (for which the ground truth is known) for assessing spike detection and spike sorting techniques. They can also be used to generate realistic (non-Gaussian) background noise. We use signals generated in this way to compare two automated spike-sorting techniques. The software is available freely on the web.
Type: Journal Article
URI: http://hdl.handle.net/1893/20650
DOI Link: http://dx.doi.org/10.1016/j.jneumeth.2006.06.019
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Computing Science - CSM Dept
University of Stirling

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